After first treatment failure

The recommendation for someone whose first 3-drug combination has failed is to switch to three or more new drugs.

If your first combination included an NNRTI then your second combination will include a boosted protease inhibitor and vice versa. This is even if a resistance test doesn’t show NNRTI or PI resistance to the first combinations.

The current recommendation is also to change to two new nukes.

If your first combination was boosted PI monotherapy, then the recommendation is to add two nukes.

Which combination to change to
After multiple treatment failure

February 2011

Decisions relating to your treatment should always be taken in consultation with your doctor. Information in this guide is intended to support those discussions.

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After first treatment failure