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Guides Hepatitis C for people living with HIV

How does HCV damage your liver?

BodyHepatitis C does not directly damage your liver. After infection, the immune system reacts to hepatitis C by trying to rid the liver of infected cells. It is this immune response that can cause liver inflammation, and this inflammation leads to scarring.

As the immune system attempts to isolate infected cells, scarring worsens.

As the liver becomes more scarred, it hardens and becomes lessĀ  elastic. This makes it increasingly difficult for blood and other fluids to flow through it.

Even though the liver can operate when badly damaged, the continuous effect of hepatitis C can slowly interfere with liver function. Complications then occur when the liver is unable to carry out important tasks.

These complications include:

  • fatty liver (steatosis)
  • jaundice
  • esophageal varices
  • ascites
  • encephalopathy
  • portal hypertension
  • kidney damage
  • thyroid disease
  • diabetes
  • appetite and weight loss resulting in malnutrition

Glossary

ascites abnormal accumulation of fluid in the abdomen, a sign of serious liver damage in people with hepatitis C

diabetes illness related to not being able to regulate sugar

encephalopathy degenerative brain function or disease

jaundice common symptom of hepatitis where increased levels of bilirubin lead to a yellowing of the skin or eyes

portal hypertension increased blood pressure (hypertension) in the vein carrying blood to the liver

varices extended or swollen veins that can burst, a complication of cirrhosis


March 2009

Decisions relating to your treatment should always be taken in consultation with your doctor. Information in this guide is intended to support those discussions.

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