Non-standard approaches

There  are other approaches than using two nukes plus either an NNRTI or boosted PI, but these have not been studied as much.

Some studies have not used nukes at all. These include a single boosted-PI, or a boosted-PI plus either an NNRTI or integrase inhibitor.

Although guidelines only recommend a few combinations, treatment is individual. Less commonly used combination will be important for some people.