HTB November/December now online

The latest edition of HTB (the last for 2011) is now online, in advance of the print edition.

Print copies will be distributed at the end of the week and should be with subscribers (subscription is free!) by next week.

Read this edition of HTB online.

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Contents

EDITORIAL

• Volume 12 Number 11/12 November/December 2011

CONFERENCE REPORTS

13TH EUROPEAN AIDS CONFERENCE (EACS), BELGRADE, SERBIA, 12–15 OCTOBER 2011

• European guidelines (EACS) – 2011 update

• Raltegravir achieves superiority over efavirenz after four years

• Higher plasma levels of tenofovir and darunavir but not efavirenz in older patients

• Ritonavir levels reduced with high fat meal

• Transplacental transfer of raltegravir and delayed plasma clearance in preterm neonates

2ND INTERNATIONAL WORKSHOP ON HIV AND AGEING, BALTIMORE, MARYLAND, 27–28 OCTOBER 2011

• Statin blocks negative impact of PIs on bone formation in vitro

• HIV linked to frailty in middle-aged IDUs, especially with poor HIV control

51ST INTERSCIENCE CONFERENCE ON ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (ICAAC) CHICAGO, 17–20 SEPTEMBER 2011

• Monitoring kidney function change with cobicistat

• Intracellular raltegravir concentrations better with twice-daily than once-daily dosing

ANTIRETROVIRALS

• Rilpivirine (Edurant) and rilpivirine/FTC/tenofovir FDC (Eviplera) approved in Europe

• FDA updates US label for darunavir for serious rash

• FDA updates US label for raltegravir due to serious rash

• Lopinavir concentrations suboptimal at reduced dose of lopinavir/ritonavir 200/50 mg twice daily

• Switching to 50mg ritonavir dose for selected protease inhibitors

• New formulations, acquisitions and company announcements

• US guidelines (DHHS) update recommendations for first-line combinations (October 2011)

PAEDIATRIC CARE

• Efavirenz under-dosing in children

• Treatment response and duration of first line treatment in European infants

OPPORTUNISTIC INFECTIONS

• US guidelines for management of older people living with HIV

• New studies on HIV and the diseases of ageing

• Risk of cataract surgery higher in HIV-positive compared to HIV-negative people

• CD4 count <200 independently associated with 5-fold increased risk of fracture

TREATMENT ACCESS

• Global Fund cancels Round 11 and introduces new rules for grant renewals

• FDA approval of generic ARVs

• We need the Patent Pool to work

BASIC SCIENCE AND IMMUNOLOGY

• Exercise as immune-based therapy

• Mapping the long genetic road to broadly neutralising antibodies

• Monkey viral reservoir study goes for gold

• Immune pressure on HIV

• Lymphocyte production capacity in HIV: links to immune activation & immune reconstitution on ART

TRANSMISSION AND PREVENTION

• International PrEP study (VOICE) discontinues use of tenofovir vaginal gel due to lack of efficacy

• UK Health Protection Agency (HPA) recommends universal HIV testing in the high incidence regions of the UK

OTHER NEWS

• Iranian doctors now freed

• New York court rejects AIDS denialist case against leading HIV community activist and journalist

• UK ban on HIV-positive doctors and dentists set to be overturned

BOOK AND FILM REVIEWS

• We Were Here

ON THE WEB

• Cure research: report from research workshop

• Free full text online articles

FUTURE MEETINGS

• Future meetings