Editorial

• Volume 1 Number 2 September-December 2008

Special reports

• OCTANE Trial DSMB finds ritonavir boosted lopinavir superior to nevirapine in HIV-positive women previously exposed to single dose nevirapine

Conference reports

• 48th ICAAC and IDSA joint meeting, 25-28 October 2008, Washington DC

• Non alcoholic fatty liver disease (NAFLD) is common among HIV-positive patients

• Antiretroviral Pregnancy Registry finds no increase in congenital anomalies with exposure to tenofovir

• No association between maternal antiretrovirals in pregnancy and congenital anomalies

• Pharmacokinetics of saquinavir/ritonavir in pregnancy

• HAART suppresses genital tract HIV shedding in HIV/HSV co-infected women

• Efavirenz significantly reduces levels of some oral contraceptives

• Lack of efficacy of isoniazid (INH) prophylaxis and PK evaluation in South African infants

• 48-week data for darunavir/ritonavir (DRV/r) in treatment-experienced children and adolescents

• Other antiretroviral studies at ICAAC

• 17th International AIDS Conference, 3-8 August 2008, Mexico City

• Bone loss in SMART study

• Abacavir and heart disease: SMART study supports an abacavir-associated increased risk of cardiovascular disease

• HAART use in pregnancy and preterm delivery and low birth weight

• New paediatric formulations of ARVs

• 3rd International Workshop on HIV Transmission, 1-2 August 2008, Mexico City

• Intermittent tenofovir/FTC PrEP offers monkeys some protection

• Tenofovir/FTC gel protects female monkeys from SHIV

• Common estimate of heterosexual HIV transmission risk sometimes far too low

Antiretrovirals

• Antiretrovirals calculated to extend life expectancy by 35 years

• FDA approves new paediatric AZT dosing

• Baseline renal insufficiency and mortality risk in HIV-positive adults in Zambia

• Inflammatory and coagulation biomarkers linked to mortality in large treatment interruption trial

PMTCT and maternal health

• Tenofovir safe in pregnancy in macaque model

• Antiretroviral therapy in pregnant women and pregnancy outcomes in Abidjan, Cote D’Ivoire

Paediatric care

• Antiretroviral therapy in HIV-positive children in Southern Africa

Treatment access

• FDA approval of generic ARVs

• Atripla to be licensed in Latin America and the Asia-Pacific region

Opportunistic infections

• Single high dose fluconazole for oropharyngeal candidiasis (OPC) comparable to standard 14-day treatment

Basic science

• Microbial translocation in immunological non-responders to ART

• Control of a superinfecting virus in an elite controller

• Second-oldest HIV-1 sequence identified

• Why do we not yet have an HIV vaccine?

Transmission

• Implications of transmission with undetectable HIV viral load: lower limit for HIV transmission excluded from model

• HIV RNA is detectable in semen in 5% patients with undetectable blood plasma viral attending fertility clinic

• Tenofovir gel as a rectal microbicide: evidence for protection and priming of T-cell responses in the SIV challenge model

• Genetic protection against malaria may increase susceptibility to HIV infection in people of African decent

PDFs

• Volume 1 Number 2 September-December 2008 PDF