Editorial

• Volume 3 Number 1 January–March 2010

Conference reports

• 17th Conference on Retroviruses and Opportunistic Infections (CROI), 16-19 February 2010, San Francisco

• No significant difference in virological failure found between once-yearly versus twice-yearly viral load monitoring in Thai study

• Model predicts rate of transmitted drug resistant virus in resource-limited settings

• More concerning research on the Free State ART programme

• Vitamin D deficiencies in HIV management

• 12th European AIDS Society Conference (EACS), 11-14 November 2009, Cologne

• Screening for anal cancer recommended for HIV-positive men

• Once-daily darunavir/r monotherapy is suboptimal as initial regimen in treatment-naïve people

• Central fat accumulation remains a significant problem in patients starting HAART after 2005 with higher incidence in women compared to men

• Gender-based differences in patients receiving antiretroviral therapy

• Pilot PK study of two generic paediatric formulations of lopinavir/ritonavir vs originator products

• TMC278 did not show teratogenic potential in animal models

• No clinically relevant interactions between TMC278 and oral contraceptives (norethindrone plus ethinylestradiol)

• Etravirine pregnancy data from five cases: no dose adjustment required

PMTCT and maternal health

• Pregnancy not nevirapine associated with risk of hepatotoxicity in large cohort comparison

• Birth defects following efavirenz exposure in a South African Hospital

Guidelines

• WHO publish major revisions to HIV management guidelines

• US guideline update: treat when CD4 is <500 cells/mm3

• Updated paediatric HIV treatment guidelines (PENTA, 2009)

Treatment access

• FDA approval of generic ARVs

• PEPFAR launches five-year strategy

• Global Fund approves US$2.4 billion in new grants

• UNITAID decision to fund ‘patent pool’ to boost access to new medicines

• Factors affecting cost of ART: Data from Aid for AIDS

Cancer and HIV

• Outcomes from screening study for anal cancer in HIV-positive compared to HIV-negative patients

Side effects

• HIV disease and renal function

Basic science

• Bridging the neurology-immunology barrier

• Early predictors of disease progression

Transmission

• Male circumcision: new data supporting protective mechanism

• A caution for male circumcision programmes: high complication rates highlighted outside a trial setting

• PRO 2000 microbicide gel does not pan out

Other news

• African civil society campaign against Uganda’s anti-homosexuality bill

• International AIDS Conference to be held in the US after over 20-year ban

On the web

• Conference reports and online abstracts

• Reports and journals

• Community resources and publications

• Medical resources

Future meetings

• 2010 conference listing

PDFs

• Volume 3 Number 1 January-March 2010 PDF