HIV Treatment Bulletin South

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Prevention

• Orange Farm circumcision results dispel concerns about risk compensation Conference reports - Prevention - Transmission - IAS 6 Rome 2011 - 1 November 2011

• DSMB stops oral tenofovir monotherapy arm of VOICE PrEP study due to lack of difference compared to placebo Prevention - 1 November 2011

• Treatment is prevention: ARV treatment in HPTN-052 reduces transmission by at least 96%: single transmission in treatment arm occurred prior to viral suppression Antiretrovirals - Conference reports - Prevention - Transmission - IAS 6 Rome 2011 - 15 August 2011

• Daily oral tenofovir/FTC PrEP reduces heterosexual transmission by 63% in the TDF2 study Antiretrovirals - Conference reports - Prevention - Transmission - IAS 6 Rome 2011 - 15 August 2011

• Tenofovir/FTC vs tenofovir as daily oral PrEP: preliminary results from Partners PrEP Antiretrovirals - Conference reports - Prevention - Transmission - IAS 6 Rome 2011 - 15 August 2011

• HPTN 052 study stopped early: significant reduction in HIV transmission from early use of HIV treatment in serodifferent partners Prevention - 15 August 2011

• FEM-PrEP prevention study using daily Truvada halted during enrollment: interim analysis shows similar infection rates in active and placebo arms Prevention - 19 May 2011

• Results from the Caprisa 004 tenofovir microbicide trial Conference reports - Prevention - Vaccines and microbicides - World AIDS 18 Vienna 2010 - 22 January 2011

• Male circumcision retains effectiveness at reducing risk of HIV infection: 54 month results Conference reports - Prevention - 22 January 2011

• Pre-exposure prophylaxis (PrEP) with tenofovir/FTC reduces sexual transmission of HIV between men at high risk: results from the iPrEx study Prevention - 22 January 2011

• US CDC issue preliminary guidance for use of PrEP Prevention - 22 January 2011

• Trial finds high adverse event rate of circumcision device being marketed in Africa Prevention - 22 January 2011

• Treatment reduces infections by over 90%: a theme that is here to stay Antiretrovirals - Conference reports - Prevention - Transmission - CROI (Retrovirus) 17 San Francisco 2010 - 2 April 2010

• Making progress on prevention Prevention - 1 October 2009

• Implications of transmission with undetectable HIV viral load: lower limit for HIV transmission excluded from model Prevention - Transmission - 22 September 2008