HIV Treatment Bulletin South

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Transmission

• International PrEP study (VOICE) discontinues use of tenofovir vaginal gel due to lack of efficacy Transmission - 28 February 2012

• Orange Farm circumcision results dispel concerns about risk compensation Conference reports - Prevention - Transmission - IAS 6 Rome 2011 - 1 November 2011

• Treatment is prevention: ARV treatment in HPTN-052 reduces transmission by at least 96%: single transmission in treatment arm occurred prior to viral suppression Antiretrovirals - Conference reports - Prevention - Transmission - IAS 6 Rome 2011 - 15 August 2011

• Daily oral tenofovir/FTC PrEP reduces heterosexual transmission by 63% in the TDF2 study Antiretrovirals - Conference reports - Prevention - Transmission - IAS 6 Rome 2011 - 15 August 2011

• Tenofovir/FTC vs tenofovir as daily oral PrEP: preliminary results from Partners PrEP Antiretrovirals - Conference reports - Prevention - Transmission - IAS 6 Rome 2011 - 15 August 2011

• Treatment reduces infections by over 90%: a theme that is here to stay Antiretrovirals - Conference reports - Prevention - Transmission - CROI (Retrovirus) 17 San Francisco 2010 - 2 April 2010

• Male circumcision: new data supporting protective mechanism Transmission - 6 January 2010

• A caution for male circumcision programmes: high complication rates highlighted outside a trial setting Transmission - 6 January 2010

• PRO 2000 microbicide gel does not pan out Transmission - 6 January 2010

• Results from HSV-2 acyclovir studies Conference reports - Opportunistic infections - Transmission - Women's health - IAS 5 Cape Town 2009 - 1 July 2009

• Intermittent tenofovir/FTC PrEP offers monkeys some protection Conference reports - Transmission - Int Transmission Workshop 3rd Mexico 2008 - 22 September 2008

• Tenofovir/FTC gel protects female monkeys from SHIV Conference reports - Transmission - Int Transmission Workshop 3rd Mexico 2008 - 22 September 2008

• Common estimate of heterosexual HIV transmission risk sometimes far too low Conference reports - Transmission - Int Transmission Workshop 3rd Mexico 2008 - 22 September 2008

• Implications of transmission with undetectable HIV viral load: lower limit for HIV transmission excluded from model Prevention - Transmission - 22 September 2008

• HIV RNA is detectable in semen in 5% patients with undetectable blood plasma viral attending fertility clinic Transmission - 22 September 2008

• Tenofovir gel as a rectal microbicide: evidence for protection and priming of T-cell responses in the SIV challenge model Transmission - 22 September 2008

• Genetic protection against malaria may increase susceptibility to HIV infection in people of African decent Transmission - 22 September 2008