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The impact of food on atazanavir/ritonavir (300/100mg once-daily) was assessed in 12 HIV-positive volunteers. When given without food, atazanavir AUC, Cmax and Ctrough decreased by 41%, 32% and 53%, respectively. Ritonavir AUC and Ctrough decreased by 26% and 53%; Cmax increased by 4%. One patient had atazanavir Ctrough below target (<150 ng/mL), but no patients showed evidence of virologic failure.

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This study indicates that food maximises the absorption of atazanavir and supports the recommendation to take atazanavir/ritoanavir with food.

Ref: Giguerre P et al. The effect of food on the pharmacokinetics of atazanavir/ritonavir 300/100mg daily in HIV-infected patients. 11th PK Workshop, 2010. Abstract 30.