HIV treatment bulletin

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2005

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• FDA fast track designation for CCR5 inhibitor vicriviroc (SCH-D) Antiretrovirals - 14 July 2005

• Pfizer discontinues development of capravirine Antiretrovirals - 14 July 2005

• Use of T-20 in pregnancy: case study shows transmission occurred in highly treatment experienced mother with multiple-drug resistance PMTCT and maternal health - 14 July 2005

• Further reading on nevirapine resistance PMTCT and maternal health - 14 July 2005

• Human Papilloma Virus vaccines – a review of advances in the development of HPV vaccines Special reports - Vaccines and microbicides - 14 July 2005

• CDC estimate over 1 million HIV-positive people in US Other news - 14 July 2005

• Newly diagnosed HIV infection – review in UK and Ireland Other news - 14 July 2005

• Re-emergence of syphilis in the UK: the new epidemic phases Other news - 14 July 2005

• Prescription of heroin is less costly for society Other news - 14 July 2005

• Medscape full text articles On the web - 14 July 2005

• HIV inSite Knowledge Base On the web - 14 July 2005

• Volume 6 Number 7 July 2005 PDF PDFs - 1 July 2005

• Volume 6 Number 6 June 2005 Editorial - 17 June 2005

• 11th BHIVA and BASSH joint annual conference, 22-25 April 2005, Dublin Conference reports - BHIVA 11th Dublin 2005 - Conference index - 15 June 2005

• Long-awaited UK pregnancy guidelines now updated; pregnancy studies in Dublin Conference reports - PMTCT and maternal health - BHIVA 11th Dublin 2005 - 15 June 2005

• Underdosing of ARVs in children: results from CHIPS cohort Conference reports - Paediatric care - BHIVA 11th Dublin 2005 - 15 June 2005

• Sexual transmission and response to treatment in acute HCV infection in HIV-positive gay men coinfected with HIV Conference reports - Hepatitis coinfection - BHIVA 11th Dublin 2005 - 15 June 2005

• Levels of efavirenz 10-fold above minimum target level despite coadministration with rifampicin Conference reports - PK and drug interactions - Side effects - BHIVA 11th Dublin 2005 - 15 June 2005

• Schistosomiasis after immune reconstitution: symptoms appear as HAART side effects Conference reports - Opportunistic infections and complications - BHIVA 11th Dublin 2005 - 15 June 2005

• 6th International Workshop on Clinical Pharmacology of HIV Therapy, 28-30 April 2005, Quebec, Canada Conference reports - Conference index - PK Workshop 6th 2005 - 15 June 2005

• Effect of age/menopause on lopinavir and efavirenz concentrations in women Conference reports - Women's health - PK Workshop 6th 2005 - 15 June 2005

• Effect of age on lopinavir concentrations Antiretrovirals - Conference reports - PK Workshop 6th 2005 - 15 June 2005

• Gender and pharmacokinetics of saquinavir Antiretrovirals - Conference reports - PK Workshop 6th 2005 - 15 June 2005

• Dosing nevirapine in children Conference reports - Paediatric care - PK Workshop 6th 2005 - 15 June 2005

• Intracellular NRTI-triphosphate levels in children are similar to adults Conference reports - Paediatric care - PK Workshop 6th 2005 - 15 June 2005

• Efavirenz and rifampicin: lower body weight associated with higher concentrations Conference reports - TB coinfection - PK Workshop 6th 2005 - 15 June 2005

• Summary of drug-drug interaction studies Conference reports - PK and drug interactions - PK Workshop 6th 2005 - 15 June 2005

• Responses to atazanavir, Kaletra and side effects Antiretrovirals - Conference reports - PK Workshop 6th 2005 - 15 June 2005

• MSF criticises Brazilian government for failing to break antiretroviral patents Treatment access - 15 June 2005

• Russian activists imprisoned for asking for treatment – letters of support requested Treatment access - 15 June 2005

• 500mg saquinavir (Invirase) approved in Europe Antiretrovirals - 15 June 2005

• Roche to withdraw saquinavir soft gel caps (Fortovase) Antiretrovirals - 15 June 2005

• FDA approve lopinavir/r once daily for treatment naive patients Antiretrovirals - 15 June 2005

• Safety data for tenofovir updated Antiretrovirals - 15 June 2005

• FDA approve entecavir for HBV Antiretrovirals - 15 June 2005

• Efavirenz warning in pregnancy strengthened Antiretrovirals - 15 June 2005

• New ritonavir interactions Antiretrovirals - 15 June 2005

• FDA advisory committee recommends approval for tipranavir – material from hearing online Antiretrovirals - 15 June 2005

• US adult treatment guidelines updated Guidelines - 15 June 2005

• Application for meltrex formulation of Kaletra submitted to the FDA Antiretrovirals - 15 June 2005

• TAC electronic newsletter On the web - 15 June 2005

• Articles from AIDS Treatment News On the web - 15 June 2005

• AIDS Vaccine Advocacy Coalition (AVAC) publishes new AIDS Vaccine Handbook On the web - 15 June 2005

• WHO lists reliable web sites on vaccines On the web - 15 June 2005

• Volume 6 Number 6 June 2005 PDF PDFs - 1 June 2005

• Volume 6 Number 5 May 2005 Editorial - 15 May 2005

• 3rd European HIV Drug Resistance Workshop, 30 March-1 April 2005, Athens Conference reports - Conference index - European Resistance Workshop 3 - 15 May 2005

• Tenofovir, nucleosides, and non-nucleosides Conference reports - Resistance - European Resistance Workshop 3 - 15 May 2005

• Protease inhibitors Conference reports - Resistance - European Resistance Workshop 3 - 15 May 2005

• CCR5 antagonists Conference reports - Resistance - European Resistance Workshop 3 - 15 May 2005

• Paediatric reports from 12th Conference on Retrovirus and Opportunistic Infections (CROI) Conference reports - Conference index - CROI 12 (Retrovirus) 2005 - 15 May 2005

• Once-daily lopinavir/ritonavir for children may offer advantages Conference reports - Paediatric care - CROI 12 (Retrovirus) 2005 - 15 May 2005

• Lopinavir/ritonavir for young infants Conference reports - Paediatric care - CROI 12 (Retrovirus) 2005 - 15 May 2005

• Paediatric dose finding atazanavir and atazanavir/ritonavir Conference reports - Paediatric care - CROI 12 (Retrovirus) 2005 - 15 May 2005

• Switching d4T to tenofovir and protease inhibitor to efavirenz Conference reports - Paediatric care - CROI 12 (Retrovirus) 2005 - 15 May 2005

• 40th European Association for the Study of the Liver (EASL) On the web - 15 May 2005

• Millions in Global Fund grants go unused: Indian government bureaucracies kill off people living with AIDS Treatment access - 15 May 2005

• Draft BHIVA treatment guidelines online for comment Guidelines - 15 May 2005

• US guidelines on paediatric care updated Guidelines - Paediatric care - 15 May 2005

• UK guidelines for liver transplant in HIV-positive patients Guidelines - Hepatitis coinfection - 15 May 2005

• Sexual HCV reinfection of HIV-positive gay man while receiving PEG-interferon plus ribavirin Hepatitis coinfection - 15 May 2005

• First European recommendations for the treatment of patients co-infected with HIV and HBV/HCV Hepatitis coinfection - 15 May 2005

• Newly acquired HIV infections are key to transmission Other news - 15 May 2005

• Calls to i-Base phoneline now free from Orange mobile networks Other news - 15 May 2005

• Request for overseas volunteers Other news - 15 May 2005

• Community impact of New York case of HIV infection with multidrug-resistant dual-tropic HIV-1 and rapid progression to AIDS On the web - 15 May 2005

• Integration of buprenorphine into primary HIV care On the web - 15 May 2005

• HIV inSite Knowledge Base On the web - 15 May 2005

• Lymphogranuloma venereum – an overview: update on UK cases of LGV Other news - Special reports - 10 May 2005

• Volume 6 Number 5 May 2005 PDF PDFs - 1 May 2005

• Volume 6 Number 4 April 2005 Editorial - 19 April 2005

• Drug-induced hepatitis in healthy volunteers receiving rifampicin 600mg daily in combination with ritonavir 100mg and saquinavir 1000mg twice daily (boosted saquinavir) Treatment alerts - 18 April 2005

• New European recommendations regarding the co-administration of ddI (Videx) and tenofovir DF (Viread) Treatment alerts - 18 April 2005

• 12th Conference on Retrovirus and Opportunistic Infections, 22-25 February, Boston, 2005 Conference reports - Conference index - CROI 12 (Retrovirus) 2005 - 18 April 2005

• Developments in nevirapine use in MTCT reduction Conference reports - PMTCT and maternal health - CROI 12 (Retrovirus) 2005 - 18 April 2005

• Mashi study – late breakers on breastfeeding Conference reports - PMTCT and maternal health - CROI 12 (Retrovirus) 2005 - 18 April 2005

• Maternal health and infant mortality Conference reports - PMTCT and maternal health - CROI 12 (Retrovirus) 2005 - 18 April 2005

• Paediatric care in lower income settings Conference reports - Paediatric care - CROI 12 (Retrovirus) 2005 - 18 April 2005

• Tenofovir not linked to bone toxicity in children followed for one year Conference reports - Paediatric care - CROI 12 (Retrovirus) 2005 - 18 April 2005

• Gut memory CD4 T cells implicated in a central role for HIV disease pathology: dramatic impact prior to seroconversion Basic science and immunology - Conference reports - CROI 12 (Retrovirus) 2005 - 18 April 2005

• Case of multi-drug resistant (MDR) rapid progressor Basic science and immunology - Conference reports - CROI 12 (Retrovirus) 2005 - 18 April 2005

• Case report of antibody reversion and negative viral load four-years after treatment discontinuation Basic science and immunology - Conference reports - CROI 12 (Retrovirus) 2005 - 18 April 2005

• 24-week efficacy of TMC114 in PI-experienced patients Antiretrovirals - Conference reports - CROI 12 (Retrovirus) 2005 - 18 April 2005

• Maturation inhibitor shows anti-HIV activity in single dose pilot study Antiretrovirals - Conference reports - CROI 12 (Retrovirus) 2005 - 18 April 2005

• New antiretrovirals at 12th CROI Antiretrovirals - Conference reports - CROI 12 (Retrovirus) 2005 - 18 April 2005

• Absolute risk is modest, but cumulative cardiovascular risk of HAART over five years is similar to 'ever smoked': new data on gender and age Conference reports - Side effects - CROI 12 (Retrovirus) 2005 - 18 April 2005

• Omega-3 supplement effective to reduce triglycerides Conference reports - Lipodystrophy and metabolic complications - Side effects - CROI 12 (Retrovirus) 2005 - 18 April 2005

• Entecavir is effective against 3TC-resistant hepatitis B Conference reports - Hepatitis coinfection - CROI 12 (Retrovirus) 2005 - 18 April 2005

• Switch to tenofovir from AZT or d4T improves fat loss and improves lipid parameters compared to abacavir Conference reports - Lipodystrophy and metabolic complications - Side effects - CROI 12 (Retrovirus) 2005 - 18 April 2005

• Continued use of a thymidine analogue may limit benefit from rosiglitazone when used to treat lipoatrophy Conference reports - Lipodystrophy and metabolic complications - Side effects - CROI 12 (Retrovirus) 2005 - 18 April 2005

• Tenofovir is non-inferior to adefovir for the treatment of hepatitis B in HBV-HIV co-infected patients Conference reports - Hepatitis coinfection - CROI 12 (Retrovirus) 2005 - 18 April 2005

• Demand for two originator ARVs could soon exceed supply Treatment access - 18 April 2005

• Indian patent bill is introduced with no change: the beginning of the end of generics? Treatment access - 18 April 2005

• Patent mailbox opened in India Treatment access - 18 April 2005

• GSK calls on UK to use G8 presidency to enforce patents Treatment access - 18 April 2005

• India admitted into Bush aid programme in same week that Indian parliament dismantles hope of future generic ARVs Treatment access - 18 April 2005

• 500mg saquinavir (Invirase) approved in Europe Antiretrovirals - 18 April 2005

• Roche discontinue ddC and Fortovase Antiretrovirals - 18 April 2005

• Needle-free injections for T-20 in US Antiretrovirals - 18 April 2005

• Pegasys approved for HIV/hepatitis C coinfection in Europe and US Hepatitis coinfection - 18 April 2005

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