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PK and drug interactions

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• Drug-drug interactions Conference reports - PK and drug interactions - PK Workshop 8th 2007 - 3 July 2007

• Drug interactions and pharmacokinetic studies: CROI 2007 Conference reports - PK and drug interactions - CROI 14 (Retrovirus) 2007 - 4 April 2007

• Drug interactions with darunavir (TMC-114) Conference reports - PK and drug interactions - HIV 8 Glasgow 2006 - 6 December 2006

• Drug interactions with etravirine (TMC-125) Conference reports - PK and drug interactions - HIV 8 Glasgow 2006 - 6 December 2006

• Critical interactions between darunavir (TMC114), lopinavir, Viagra, and oral contraceptives Conference reports - PK and drug interactions - ICAAC 46th San Francisco 2006 - 7 October 2006

• Relationship between nevirapine concentrations and virological failure in a clinical setting Conference reports - PK and drug interactions - PK Workshop 7th 2006 - 11 June 2006

• Summary of drug interaction studies Conference reports - PK and drug interactions - PK Workshop 7th 2006 - 11 June 2006

• Effects of ketoconazole and rifampin on TMC278 Conference reports - PK and drug interactions - PK Workshop 7th 2006 - 10 June 2006

• Brecanavir interaction study with ritonavir and atazanavir Conference reports - PK and drug interactions - PK Workshop 7th 2006 - 10 June 2006

• Dosing rifabutin and lopinavir/r – sub-optimal rifabutin levels reported in five patients dosed according to current guidelines Conference reports - PK and drug interactions - TB coinfection - BHIVA 12th Brighton 2006 - 12 May 2006

• Pharmacology and drug interaction studies in adults: summary table from CROI, ICAAC and EACS conferences Conference reports - PK and drug interactions - CROI 13 (Retrovirus) 2006 - EACS 10 Dublin 2005 - ICAAC 45th Washingon 2005 - 12 April 2006

• Nelfinavir reduces pravastatin AUC by 46% in HIV-negative volunteers PK and drug interactions - 11 April 2006

• Overview of pharmacology studies Conference reports - PK and drug interactions - IAS 3 Rio de Janeiro 2005 - 14 September 2005

• Levels of efavirenz 10-fold above minimum target level despite coadministration with rifampicin Conference reports - PK and drug interactions - Side effects - BHIVA 11th Dublin 2005 - 15 June 2005

• Summary of drug-drug interaction studies Conference reports - PK and drug interactions - PK Workshop 6th 2005 - 15 June 2005

• Atazanavir boosts intracellular saquinavir levels: data on important new dual-boosted regimen Antiretrovirals - Conference reports - PK and drug interactions - HIV 7 Glasgow 2004 - 29 March 2005

• Interactions between African herbal medicines and ARVs PK and drug interactions - 29 March 2005

• Atorvastatin requires dose reduction with tipranavir/r Conference reports - PK and drug interactions - ICAAC 44th Washington 2004 - 29 January 2005

• Fluconazole increases nevirapine levels and risk of serious hepatotoxicity Conference reports - PK and drug interactions - World AIDS 15 Bangkok 2004 - 6 September 2004

• Efavirenz interaction with rifampin may not require dose adjustment in patients with low body weight Conference reports - PK and drug interactions - World AIDS 15 Bangkok 2004 - 6 September 2004

• Tipranavir significantly lowers doses of saquinavir, amprenavir and lopinavir/r Conference reports - PK and drug interactions - World AIDS 15 Bangkok 2004 - 6 September 2004

• Non-prescription simvastatin in the UK: contraindicated with many HIV medications PK and drug interactions - 29 July 2004

• Label changes for indinavir warn of several interactions including atazanavir and PDE5 inhibitors PK and drug interactions - 29 July 2004

• 5th International Workshop on Clinical Pharmacology of HIV Therapy, 1-3 April 2004, Rome, Italy Conference reports - PK and drug interactions - Conference index - PK Workshop 5th 2004 - 2 May 2004

• Large reductions in plasma PK levels of saquinavir, amprenavir and lopinavir/r levels when given with tipranavir/ritonavir Conference reports - PK and drug interactions - PK Workshop 5th 2004 - 2 May 2004

• Good generic drugs and good adherence in Rwanda Conference reports - PK and drug interactions - Treatment access - PK Workshop 5th 2004 - 2 May 2004

• Steady state PK of nelfinavir and M8 in pregnancy Conference reports - PK and drug interactions - PMTCT and maternal health - TB coinfection - PK Workshop 5th 2004 - 2 May 2004

• Higher nelfinavir concentrations improve response in children Conference reports - PK and drug interactions - Paediatric care - PK Workshop 5th 2004 - 2 May 2004

• PK of once daily lopinavir/r in children Conference reports - PK and drug interactions - Paediatric care - PK Workshop 5th 2004 - 2 May 2004

• Eating grapefruit triggers statin-related rhabdomyolysis PK and drug interactions - Side effects - 2 May 2004

• Drug levels can persist for more than two weeks after stopping efavirenz Antiretrovirals - Conference reports - PK and drug interactions - CROI 11 (Retrovirus) 2004 - 3 April 2004

• Race affects absorption and clearance of efavirenz Conference reports - PK and drug interactions - Side effects - CROI 11 (Retrovirus) 2004 - 3 April 2004

• Triple PI interactions: atazanavir increases saquinavir levels in ritonavir-boosted once-daily combination Conference reports - PK and drug interactions - CROI 11 (Retrovirus) 2004 - 3 April 2004

• Triple PI interactions: fosamprenavir and Kaletra interaction is difficult to overcome Conference reports - PK and drug interactions - CROI 11 (Retrovirus) 2004 - 3 April 2004

• Ribavirin (RBV) does not alter intracellular levels of AZT, 3TC or d4T Conference reports - Hepatitis coinfection - PK and drug interactions - CROI 11 (Retrovirus) 2004 - 3 April 2004

• Interaction between amprenavir and lopinavir thwarts triple PI salvage PK and drug interactions - 1 November 2003

• Vitamin C induces P4503A4 and reduces indinavir levels PK and drug interactions - 1 November 2003

• Indinavir levels reduced by omeprazole PK and drug interactions - 1 November 2003

• Boosted saquinavir PK in once-daily regimes PK and drug interactions - 1 November 2003

• Tenofovir drug-drug interactions PK and drug interactions - 1 November 2003

• Summary of other PK studies PK and drug interactions - 1 November 2003

• Uridine as a potential treatment for NRTI related mitochondrial toxicity Conference reports - PK and drug interactions - Side effects - Lipodystrophy Workshop (IWADRW) 5 Paris 2003 - 1 September 2003

• Pharmacology studies at the 2nd IAS conference Antiretrovirals - Conference reports - PK and drug interactions - PMTCT and maternal health - IAS 2 Paris 2003 - 1 September 2003

• 4th International Workshop on Clinical Pharmacology of HIV Therapy, 27-29 March 2003, Cannes, France Conference reports - PK and drug interactions - Conference index - PK Workshop 4th 2003 - 1 May 2003

• Can low NVP plasma concentrations explain the results seen in the EFV and NVP containing arms of the NARVAL study? Conference reports - PK and drug interactions - PK Workshop 4th 2003 - 1 May 2003

• Up to one third of patients receiving standard doses of NNRTIs may be being underdosed Conference reports - PK and drug interactions - PK Workshop 4th 2003 - 1 May 2003

• Nelfinavir concentrations are significantly higher in HIV/HCV co-infected patients with cirrhosis Conference reports - PK and drug interactions - PK Workshop 4th 2003 - 1 May 2003

• Less diarrhoea and bioequivalence with the new nelfinavir 625mg tablet Antiretrovirals - Conference reports - PK and drug interactions - Side effects - PK Workshop 4th 2003 - 1 May 2003

• The potential for probenecid to have a serious interaction with HIV-1 protease inhibitors Conference reports - PK and drug interactions - Side effects - PK Workshop 4th 2003 - 1 May 2003

• PK studies reveal significant sex/gender differences Conference reports - PK and drug interactions - Women's health - PK Workshop 4th 2003 - 1 May 2003

• Pregnancy-related PK studies Conference reports - PK and drug interactions - PMTCT and maternal health - PK Workshop 4th 2003 - 1 May 2003

• New test to measure intracellular levels of nucleosides Conference reports - PK and drug interactions - PK Workshop 4th 2003 - 1 May 2003

• Case studies for therapeutic drug monitoring (TDM) Conference reports - PK and drug interactions - PK Workshop 4th 2003 - 1 May 2003

• Launch of guide to the use of drug level monitoring Conference reports - PK and drug interactions - PK Workshop 4th 2003 - 1 May 2003

• Pharmacokinetic papers from 10th CROI Conference reports - PK and drug interactions - CROI 10 (Retrovirus) 2003 - 1 May 2003

• NIH/NIAID study of generic drugs shows results consistent with stringent manufacturing standards Antiretrovirals - Conference reports - PK and drug interactions - Treatment access - CROI 10 (Retrovirus) 2003 - 1 April 2003

• Low dose 200/100 IDV/RTV managed by TDM in substudy of co-infected patients Conference reports - Hepatitis coinfection - PK and drug interactions - CROI 10 (Retrovirus) 2003 - 1 April 2003

• Pharmacokinetic evaluation of tenofovir and enteric-coated ddI Antiretrovirals - Conference reports - PK and drug interactions - HIV 6 Glasgow 2003 - 1 February 2003

• Milk thistle can reduce levels of indinavir in the blood PK and drug interactions - 13 November 2002

• US FDA announces important changes in amprenavir product labelling Antiretrovirals - PK and drug interactions - 13 October 2002

• St John’s Wort interferes with chemotherapy, study shows Cancer and HIV - PK and drug interactions - 13 October 2002

• Garlic can impede HIV medication PK and drug interactions - 9 December 2001

• Caution needed with nelfinavir and some lipid-lowering drugs PK and drug interactions - 9 December 2001

• Combinations of lopinavir/r and amprenavir in heavily treatment experienced patients Conference reports - PK and drug interactions - EACS 8 Athens 2001 - 2 November 2001

• No significant drug interactions found between tenofovir DF and indinavir, lopinavir/r, lamivudine, or efavirenz Conference reports - PK and drug interactions - EACS 8 Athens 2001 - 2 November 2001

• Ritonavir corrects drug interaction between efavirenz and saquinavir Conference reports - PK and drug interactions - EACS 8 Athens 2001 - 2 November 2001

• Pharmacology at 1st IAS Conference reports - PK and drug interactions - IAS 1 Buenos Aires 2001 - 1 September 2001

• Drug-drug interactions Conference reports - PK and drug interactions - IAS 1 Buenos Aires 2001 - 1 September 2001

• A warning about milk thistle (silymarin) and drug interactions PK and drug interactions - 30 July 2001

• Interaction between garlic and saquinavir and underreporting of alternative treatment use Conference reports - PK and drug interactions - Special reports - CROI 8 (Retrovirus) 2001 - 17 March 2001

• Drug interactions: amprenavir, saquinavir, ABT-378/r (lopinavir/r), indinavir, efavirenz, ritonavir Conference reports - PK and drug interactions - PK Workshop 1st 2000 - 15 May 2000

• St John's Wort: message from Professor A Breckenridge, Chair, Committee on Safety of Medicines. PK and drug interactions - Treatment alerts - 14 April 2000

• Interactions of St John's Wort (Hypericum perforatum) preparations PK and drug interactions - 14 April 2000

• Important safety information for people taking St John's Wort preparations PK and drug interactions - 14 April 2000

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