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The efavirenz trough concentrations in 17 HIV+ subjects with substance related disorders (SRDs) and 20 HIV-positive subjects without SRDs were evaluated. The median efavirenz trough concentrations in the SRD groups were lower with tobacco (1.76 vs 2.295 ug/ml), alcohol (1.41 vs 2.25 ug/ml), marijuana (1.73 vs 2.24 ug/ml) and cocaine (1.92 vs 2.05mg/ml), but higher with opioids (2.41 vs 1.85 mg/ml). Only the differences with tobacco and alcohol were statistically significant. There was no significant relationship between SRD and antiviral response.

Ref: Meeting Report – 49th ICAAC, San Francisco, September 2009. 49th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, September 2009.

http://www.hiv-druginteractions.org/data/NewsItem/79_ICAAC49.pdf