What happens if I take efavirenz and Truvada after a meal?
What is the consequences of taking truvada efevirenz immediately after meal?
Short answer is that you will not do any harm, other than perhaps having more unpleasant side effects from efavirenz.
This is because a high fat meal will increase drug levels of efavirenz but about 60%. This is often enough to change you mood, make your sleep worse, increase chance of nightmares etc and that the side effect might make you feel worse the next day.
However, if you don;t get these side effects and want to take your meds with food, you are not risking a lower dose, just a higher one.
Food also boosts levels of tenofovir (in Truvada) by about 30%.