Q and A

Question

Can I change from lamzid & aluvia to Atripla?

I was taking aspen lamzid (AZT/3TC) and Aluvia (lopinavir/r),and now it turns out i have to take Atripla (efavirenz, FTC + tenofovir). Is is safe to do so? Won’t my body develop resistance towards the meds?

Answer

Hello,

Thank-you for your email.

To answer your question I would need to know why you are changing medication.

If you are changing because you had virological failure- which means your viral load went up- then there is risk that you have resistance to some HIV medications, which may affect your use of Atripla. This is because resistance to AZT or 3TC can mean you also have resistance to FTC or tenofovir.

If you are changing for another reason, and have no resistance to AZT or 3TC, then it should be OK to switch.

54 comments

  1. Simon Collins

    Hi Fikelephi, most countries have alternative combinations that you could use. Both the drus you are on are quite old now. Are you taking these twice a day? Please talk to your doctor about the reasons you want to change and if there are alternatives. Many people use once-daily treatment, but this might also depend on your previous HIV history.

  2. Fikelephi

    I would to know whether is possible for me to change Aluvia and Lamzid to another regiment

  3. Simon Collins

    Hi Thully, thanks – and great you are doing so well on your meds. It is very safe to switch to TDL – also sometimes called TLD. This is generally a bettr meds and you might find it easier. Ther is more info here:
    https://i-base.info/guides/14970

  4. Thully

    Hi guys Im on alluvia and lamzid for ayear,my viral load less than 20 copies is it safe to change to TDL,there will be no complications?

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