Cross-resistance by drug class

There are six main types (or classes) of drugs that work at different parts of the HIV life cycle.


Cross-resistance between NRTIs is complex. Some drugs are active even with some resistance.


There is strong cross-resistance between some NNRTIs. But, etravirine can work against other NNRTI resistance.

Protease inhibitors (PIs)

There is strong cross-resistance between some PIs. Some PIs, including darunavir/r and tipranavir/r, can work against early PI resistance.

Integrase inhibitors

As a new class, integrase inhibitors work if you have resistance to other drug classes. But they can also have cross-resistance within the class.

Resistance to raltegravir or elvitegravir can sometimes be overcome by dolutegravir by using a higher dose.

Dolutegravir has stronger barrier to drug resistance than other currently approved integrase inhibitors.

Last updated: 1 January 2018.