Cross-resistance by drug class
There are six main types (or classes) of drugs that work at different parts of the HIV life cycle.
Cross-resistance between NRTIs is complex. Some drugs are active even with some resistance.
There is strong cross-resistance between some NNRTIs. But, etravirine can work against other NNRTI resistance.
Protease inhibitors (PIs)
There is strong cross-resistance between some PIs. Some PIs, including darunavir/r and tipranavir/r, can work against early PI resistance.
As a new class, integrase inhibitors work if you have resistance to other drug classes. But they can also have cross-resistance within the class.
Resistance to raltegravir or elvitegravir can sometimes be overcome by dolutegravir by using a higher dose.
Dolutegravir has stronger barrier to drug resistance than other currently approved integrase inhibitors.
- Information on each HIV drug.
- Table of six main types (or classes) of HIV drugs
- Diagram of the HIV lifecyle.
Last updated: 1 January 2018.