{"id":1051,"date":"2024-11-01T12:00:14","date_gmt":"2024-11-01T12:00:14","guid":{"rendered":"http:\/\/localhost.localdomain\/wpmu\/guides\/?page_id=1051"},"modified":"2024-11-25T18:18:52","modified_gmt":"2024-11-25T18:18:52","slug":"introduction-to-daas","status":"publish","type":"page","link":"https:\/\/i-base.info\/guides\/hepc\/introduction-to-daas","title":{"rendered":"Introduction to DAAs: treatment and management"},"content":{"rendered":"<h2>Treating HCV<\/h2>\n<p><b><strong><img loading=\"lazy\" decoding=\"async\" class=\"alignright size-full wp-image-1608\" src=\"https:\/\/i-base.info\/guides\/files\/2009\/06\/roundel-small.png\" alt=\"Pattern\" width=\"150\" height=\"146\" \/><\/strong>DAA stands for direct-acting antivirals.<span class=\"Apple-converted-space\">\u00a0<\/span><\/b><\/p>\n<p>DAAs cure HCV in more than 95% of people. This usually involves just one or two pills a day for 8 to12 weeks.<\/p>\n<p>Thia lao involves very few or only mild side effects.<\/p>\n<h2>Different DAA classes<\/h2>\n<p>As with HIV drugs, each class of DAA works at a different stage of the HCV life cycle.<span class=\"Apple-converted-space\">\u00a0<\/span><\/p>\n<p>DAAs are also used in combinations.<span class=\"Apple-converted-space\">\u00a0<\/span><\/p>\n<p>The three classes are:<\/p>\n<ul>\n<li>HCV protease inhibitors (PIs).<\/li>\n<li>Nucleotide polymerase inhibitors.<span class=\"Apple-converted-space\">\u00a0<\/span><\/li>\n<li>NS5A inhibitors.<span class=\"Apple-converted-space\">\u00a0<\/span><\/li>\n<\/ul>\n<p>Adherence is very important. This is defined as taking more than 95% of doses on time.<\/p>\n<h2>What are the goals of treatment?<\/h2>\n<p><b>There are two goals of HCV treatment.<\/b><\/p>\n<p>One is to cure HCV and the other is to improve liver health.<\/p>\n<p><b>Goal 1: curing HCV<\/b><\/p>\n<p>The first goal of treatment is to clear HCV. This is called a cure.<span class=\"Apple-converted-space\">\u00a0<\/span><\/p>\n<p>A cure is defined as having an undetectable HCV viral load during 12 weeks after the last dose (SVR-12). SVR stands for sustained viral (or virologic) response.<\/p>\n<p>Up to 99% of people who have an SVR-12 stay HCV-free. This is regardless of HIV status.<span class=\"Apple-converted-space\">\u00a0<\/span><\/p>\n<p>Although HCV can sometimes return after treatment is finished, this is usually within four weeks.<span class=\"Apple-converted-space\">\u00a0<\/span><\/p>\n<p>However, being cured does not protect you against HCV reinfection.<\/p>\n<p><b>Goal 2: improving liver health<\/b><\/p>\n<p>The second goal of HCV treatment is to improve liver health.<\/p>\n<p>This occurs from reducing liver inflammation. As well as preventing further damage, fibrosis can sometimes be partially reversed. These improvements usually happen in people who are cured.<span class=\"Apple-converted-space\">\u00a0<\/span><\/p>\n<p>Being cured reduces the risk of liver cirrhosis, liver cancer and liver failure in both HIV negative and HIV positive people.<span class=\"Apple-converted-space\">\u00a0<\/span><\/p>\n<p>In HIV positive people, a cure lowers the risk of death from liver-related and HIV-related causes, even with cirrhosis.<\/p>\n<p>HCV treatment might also reduce liver-related side effects from ART.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Treating HCV DAA stands for direct-acting antivirals.\u00a0 DAAs cure HCV in more than 95% of people. This usually involves just one or two pills a day for 8 to12 weeks. Thia lao involves very few or only mild side effects. &hellip;<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":18,"menu_order":23,"comment_status":"open","ping_status":"closed","template":"page-guides.php","meta":{"footnotes":""},"class_list":["post-1051","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/pages\/1051","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/comments?post=1051"}],"version-history":[{"count":6,"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/pages\/1051\/revisions"}],"predecessor-version":[{"id":18032,"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/pages\/1051\/revisions\/18032"}],"up":[{"embeddable":true,"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/pages\/18"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/media?parent=1051"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}