{"id":11572,"date":"2025-11-01T12:00:00","date_gmt":"2025-11-01T12:00:00","guid":{"rendered":"http:\/\/i-base.info\/guides\/?page_id=11572"},"modified":"2025-11-20T13:23:40","modified_gmt":"2025-11-20T13:23:40","slug":"real-life-examples-for-on-demand-dosing","status":"publish","type":"page","link":"https:\/\/i-base.info\/guides\/prep\/real-life-examples-for-on-demand-dosing","title":{"rendered":"Examples of event-based 2:1:1 and 2:7 dosing"},"content":{"rendered":"

The following examples show different doses for on-demand dosing.<\/strong><\/p>\n

1. Event-based 2:1:1 dosing: sex once<\/h2>\n

2:1:1 dosing can be used by anyone having insertive sex or receptive anal sex.<\/b><\/p>\n

\"\"<\/a><\/p>\n

If you might have sex on Thursday, take a double dose at least two hours before you have sex.<\/b><\/p>\n

Then take a single pill for the next two<\/b> days. This should be roughly 24 hours and 48 hours after the first double dose.<\/p>\n

These times can be approximate. You still get good protection even if you have sex earlier or later than planned. <\/i>Even if the pre-dose is only just before or even after sex, some PrEP is always better than none.<\/b><\/p>\n

If you have sex several times over a few days, keep taking a pill each day. Continue for two days after the last day you have sex.<\/i><\/b><\/p>\n

2.\u00a0Event-based 2:1:1 dosing: more sex!<\/h2>\n

If you have sex over a few days, keep taking a pill each day. Continue for two days after the last day you have sex.<\/b><\/p>\n

\"\"<\/a><\/p>\n

If you have sex over several days, continue to take a single pill every day you have sex at around the same time.<\/p>\n

Then after you stop having sex, take daily PrEP for the next two days.\u00a0<\/span><\/p>\n

If you start PrEP but then don\u2019t have sex \u2013 and you have no plans to have sex \u2013 there is no need to keep taking PrEP.\u00a0<\/span><\/p>\n

3. Event-based 2:7 dosing<\/h2>\n

2:7 dosing is sometimes needed by cis women and trans and non-binary people having receptive vaginal\/frontal sex.<\/b><\/p>\n

\"\"<\/a><\/p>\n

If you are a cisgender woman, or are transgender or non-binary, having receptive vaginal or frontal sex might need daily PrEP to continue for seven days.<\/b><\/p>\n

This is for situations when you didn\u2019t take at least four doses of PrEP the previous week.<\/b><\/p>\n

Start with a double dose before sex and then take daily PrEP for seven<\/b> days after sex, at roughly the same time each day.<\/p>\n

Some researchers think that fewer doses after sex would also be okay, for example, 2:1:1:1 dosing. This is based on drug levels reached by this dosing though and isn’t included in guidelines.<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

The following examples show different doses for on-demand dosing. 1. Event-based 2:1:1 dosing: sex once 2:1:1 dosing can be used by anyone having insertive sex or receptive anal sex. If you might have sex on Thursday, take a double dose …<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":11507,"menu_order":19,"comment_status":"closed","ping_status":"closed","template":"page-guides.php","meta":{"footnotes":""},"class_list":["post-11572","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/pages\/11572","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/comments?post=11572"}],"version-history":[{"count":3,"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/pages\/11572\/revisions"}],"predecessor-version":[{"id":19131,"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/pages\/11572\/revisions\/19131"}],"up":[{"embeddable":true,"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/pages\/11507"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/media?parent=11572"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}