{"id":2177,"date":"2023-03-01T12:00:28","date_gmt":"2023-03-01T12:00:28","guid":{"rendered":"http:\/\/moomango.co.uk\/guides\/?page_id=2177"},"modified":"2023-03-13T07:45:39","modified_gmt":"2023-03-13T07:45:39","slug":"skin-rash","status":"publish","type":"page","link":"https:\/\/i-base.info\/guides\/side\/skin-rash","title":{"rendered":"Skin rash"},"content":{"rendered":"<p><strong><img loading=\"lazy\" decoding=\"async\" class=\"alignright size-full wp-image-2178\" src=\"https:\/\/i-base.info\/guides\/files\/2009\/07\/rash.png\" alt=\"Bloke with spotty face\" width=\"150\" height=\"193\" \/>Many drugs are associated with rash including: <a href=\"https:\/\/i-base.info\/guides\/3521#more-3521\">abacavir<\/a> (Ziagen and in Kivexa, Triumeq and Trizivir), <a href=\"https:\/\/i-base.info\/guides\/3535#more-3535\">FTC<\/a> (Emtriva), <a href=\"https:\/\/i-base.info\/guides\/3543#more-3543\">nevirapine<\/a> (Viramune), <a href=\"https:\/\/i-base.info\/guides\/734#more-734\">efavirenz<\/a> (Sustiva), <a href=\"https:\/\/i-base.info\/guides\/3569#more-3569\">etravirine<\/a> (Intelence), <a href=\"https:\/\/i-base.info\/guides\/3551#more-3551\">fosamprenavir<\/a> (Lexiva\/Telzir), <a href=\"https:\/\/i-base.info\/guides\/3545#more-3545\">atazanavir<\/a> (Reyataz), <a href=\"https:\/\/i-base.info\/guides\/3555#more-3555\">darunavir<\/a> (Prezista), <a href=\"https:\/\/i-base.info\/guides\/3561#more-3561\">tipranavir<\/a> (Aptivus), <a href=\"https:\/\/i-base.info\/guides\/3567#more-3567\">raltegravir<\/a> (Isentress) and <a href=\"https:\/\/i-base.info\/guides\/3571#more-3571\">T-20<\/a> (enfuvirtide, Fuzeon).<\/strong><\/p>\n<p><strong>Although many drugs are linked to rash, the severity of rash and how long it lasts can vary\u00a0a lot.<\/strong><\/p>\n<p>With some drugs, if you develop a rash during the first few weeks of therapy you must report this immediately to your doctor. This is because it can sometimes lead to very serious reactions.<\/p>\n<p>Other rashes can be mild and disappear without treatment, or can be easily treated with antihistamine drugs such as cetirizine (Zirtek) or loratadine (Claritin).<\/p>\n<p><b>Atazanavir<\/b> can cause a mild rash during the first two months in 10% of people but this disappears without additional treatment within a few weeks.<\/p>\n<p><b>Emtricitabine <\/b>studies reported rash on the palms of the hands or feet in up to 10% of African Americans, but these have been reported less frequently since the drug was licensed.<\/p>\n<p>Although antihistamines are available over the counter, it is important that you check with your doctor or pharmacist before taking them, as there can be interactions with HIV drugs.<\/p>\n<p>A rash can also occur as a reaction from exposure to the sun, and will normally resolve. Any rash that makes you feel sick might not be a side effect but a symptom of an underlying disease (such as scabies).<\/p>\n<h2>Nevirapine rash with liver toxicity<\/h2>\n<p>Nevirapine is linked to two different types of rash. One is the hypersensitivity-type reaction, probably linked to genetic risk factors.<\/p>\n<p>The second is a rash that is related to liver toxicity, and this is more likely to be cause by an immune-related problem, and from starting nevirapine at a high CD4 count.\u00a0See\u00a0<a href=\"https:\/\/i-base.info\/guides\/side\/liver-related-side-effect\">liver toxicity<\/a>.<\/p>\n<h2>Things that can help<\/h2>\n<ul>\n<li>Bath or shower in cool or warm water rather than hot water as this can irritate your rash.<\/li>\n<li>Avoid heavily scented or coloured soaps and shower gels. Try to use products that are marked hypoallergenic or wash with aqueous cream.<\/li>\n<li>Use liquids and not powder to wash your clothes as tiny amounts of powder can build up on your clothes. Try using non-biological products\u00a0that are designed for sensitive skin.<\/li>\n<li>Wear cool fibres such as cotton rather than synthetic ones. When possible at home wear as few clothes as possible.<\/li>\n<li>Try not to use too many bedclothes. Keep as cool as possible in bed as being too warm can irritate your rash. Again, use natural, cool fibres such as cotton.<\/li>\n<li>Calamine lotion can be soothing when a rash is irritating.<\/li>\n<\/ul>\n<h2>NNRTI rash (nevirapine, efavirenz and etravirine)<\/h2>\n<p>Up to 20% of people using nevirapine, efavirenz or etravirine, can experience a mild to moderate rash in the first weeks of treatment.<\/p>\n<p>For most people this disappears over the next few weeks and they experience no further side effects. Less than 5% of people stop an NNRTI because of rash, and less than 1% people (0.1\u20130.5%) get a severe (grade 4) rash.<\/p>\n<p>Nevirapine is no longer used for starting treatment in the UK but it might occasionally be used as a switch treatment.<\/p>\n<p>If you get a rash with an NNRTI, you should make sure your doctor checks this carefully.<\/p>\n<p><b>Anything more than a mild rash might require stopping the NNRTI\u00a0\u2013 but only on the advice of your doctor.<\/b><\/p>\n<p><b>More serious rash (0.3% with nevirapine, 0.1% with efavirenz, less than 0.1% with etravirine) can be life-threatening.\u00a0<\/b><\/p>\n<p><b>Stevens-Johnson Syndrome (SJS) is a severe hypersensitivity rash and stopping treatment is essential. This is why a rash needs to be seen by a doctor.<\/b><\/p>\n<h2>Abacavir and rash<\/h2>\n<p>A rash can sometimes be one of the symptoms of the hypersensitivity reaction associated with abacavir (also in Ziagen, Kivexa and Trizivir) that occurs in 4-5% of people using abacavir.<\/p>\n<p><b>It is essential that you see your doctor if a rash appears when using abacavir in a combination.\u00a0<\/b><\/p>\n<p><a href=\"..\/abacavir-hypersensitivity-reaction\/\">Abacavir hypersensitivity reaction<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Many drugs are associated with rash including: abacavir (Ziagen and in Kivexa, Triumeq and Trizivir), FTC (Emtriva), nevirapine (Viramune), efavirenz (Sustiva), etravirine (Intelence), fosamprenavir (Lexiva\/Telzir), atazanavir (Reyataz), darunavir (Prezista), tipranavir (Aptivus), raltegravir (Isentress) and T-20 (enfuvirtide, Fuzeon). Although many drugs &hellip;<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":291,"menu_order":23,"comment_status":"closed","ping_status":"closed","template":"page-guides.php","meta":{"footnotes":""},"class_list":["post-2177","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/pages\/2177","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/comments?post=2177"}],"version-history":[{"count":1,"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/pages\/2177\/revisions"}],"predecessor-version":[{"id":16645,"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/pages\/2177\/revisions\/16645"}],"up":[{"embeddable":true,"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/pages\/291"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/media?parent=2177"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}