{"id":2213,"date":"2023-03-01T12:00:00","date_gmt":"2023-03-01T12:00:00","guid":{"rendered":"http:\/\/moomango.co.uk\/guides\/?page_id=2213"},"modified":"2023-03-13T07:48:33","modified_gmt":"2023-03-13T07:48:33","slug":"abacavir-hypersensitivity-reaction","status":"publish","type":"page","link":"https:\/\/i-base.info\/guides\/side\/abacavir-hypersensitivity-reaction","title":{"rendered":"Abacavir hypersensitivity reaction (HSR)"},"content":{"rendered":"

\"Hey!\"Associated drugs: abacavir <\/a>(Ziagen), Trizivir<\/a> (abacavir+AZT+3TC ), Kivexa<\/a> (abacavir+3TC), Triumeq<\/a>\u00a0(abacavir+3TC+dolutegravir) and\u00a0cotrimoxazole (Septrin).\u00a0HSR with other HIV drugs is rare.<\/strong><\/p>\n

The main side effect associated with abacavir is a hypersensitivity reaction (HSR) which used to occur in around 5% of people. However, using a screening test (called HLA-B*5701), reduces this risk to less than 1%.<\/strong><\/p>\n

However, a screening test (called HLA-B*5701), reduces this risk to less than 1%. This test is recommended in the UK before<\/i> using abacavir.<\/p>\n

HSR means that the body is oversensitive to a drug. Hypersensitivity reactions can also occur with raltegravir, dolutegravir, nevirapine, T-20, fosamprenavir and cotrimoxazole (Septrin). Genetic tests are only available for abacavir.<\/p>\n

Hypersensitivity reaction to abacavir occurs during the first six weeks of therapy in over 90% of cases. Rarely, it can occur much later without any previous symptoms.<\/p>\n

You need to know the symptoms of abacavir HSR before starting therapy, even if the B*5701 genetic test is negative. If you get symptoms from two or more of the following groups, call your doctor straight away.<\/p>\n

    \n
  1. Fever.<\/li>\n
  2. Rash.<\/li>\n
  3. Nausea, vomiting, diarrhea, or stomach pain.<\/li>\n
  4. Generally ill feeling, extreme tiredness, or aches.<\/li>\n
  5. Shortness of breath, cough, or sore throat.<\/li>\n<\/ol>\n

    These general symptoms can be mistaken for other illnesses including cold, flu and chest infections, especially during the winter.<\/p>\n

    A few people who test negative for B*5701 might\u00a0still get HSR.<\/p>\n

    If the symptoms get progressively worse each day it is an indication that this is HSR. A rash is not always present.<\/p>\n

    Do not stop taking your medication until you have seen a doctor and a diagnosis of hypersensitivity has been made.<\/b><\/p>\n

    If you stop using abacavir before you have seen a doctor with these symptoms then you will not be able to restart, as hypersensitivity cannot then be ruled out. This means you will be reducing your future treatment options.<\/p>\n

    If HSR is diagnosed by a doctor then abacavir will be stopped straight away. These symptoms should then disappear very quickly after abacavir is stopped.<\/p>\n

    Abacavir must never be restarted at any time in the future if you have had the hypersensitivity reaction, as this can prove fatal.<\/b><\/p>\n

    Abacavir is also included in these formulations:<\/p>\n

      \n
    • Kivexa (abacavir+3TC).<\/li>\n
    • Triumeq (abacavir+3TC+dolutegravir).<\/li>\n
    • Trizivir (abacavir+AZT+3TC).<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"

      Associated drugs: abacavir (Ziagen), Trizivir (abacavir+AZT+3TC ), Kivexa (abacavir+3TC), Triumeq\u00a0(abacavir+3TC+dolutegravir) and\u00a0cotrimoxazole (Septrin).\u00a0HSR with other HIV drugs is rare. The main side effect associated with abacavir is a hypersensitivity reaction (HSR) which used to occur in around 5% of people. However, …<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":291,"menu_order":35,"comment_status":"closed","ping_status":"closed","template":"page-guides.php","meta":{"footnotes":""},"class_list":["post-2213","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/pages\/2213","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/comments?post=2213"}],"version-history":[{"count":1,"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/pages\/2213\/revisions"}],"predecessor-version":[{"id":16624,"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/pages\/2213\/revisions\/16624"}],"up":[{"embeddable":true,"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/pages\/291"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/media?parent=2213"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}