{"id":13594,"date":"2018-05-12T12:00:21","date_gmt":"2018-05-12T12:00:21","guid":{"rendered":"http:\/\/i-base.info\/guides\/?p=13594"},"modified":"2022-01-05T14:24:50","modified_gmt":"2022-01-05T14:24:50","slug":"symtuza","status":"publish","type":"post","link":"https:\/\/i-base.info\/guides\/13594","title":{"rendered":"Symtuza (darunavir + cobicistat + emtricitabine + TAF)"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-13805\" src=\"https:\/\/i-base.info\/guides\/wp-content\/uploads\/2017\/10\/Symtuza-2018.png\" alt=\"\" width=\"126\" height=\"73\" \/><br \/>\n<!--more--><br \/>\n<em>sim-TOO-za<\/em><\/p>\n<ul>\n<li>Symtuza is a fixed dose combination that contains\u00a0<a href=\"https:\/\/i-base.info\/guides\/3555\">darunavir<\/a>, <a href=\"https:\/\/i-base.info\/guides\/8930\">cobicistat<\/a>, <a href=\"https:\/\/i-base.info\/guides\/3535\">emtricitabine<\/a> and <a href=\"https:\/\/i-base.info\/guides\/11059\">tenofovir alafenamide<\/a>.<\/li>\n<li>Standard dose is to take one pill once-daily.<\/li>\n<li>Symtuza needs to be taken with food.<\/li>\n<li>\n<div class=\"page\" title=\"Page 2\">\n<div class=\"layoutArea\">\n<div class=\"column\">\n<p>Symtuza is approved for adults and adolescents (aged 12 years and older with body weight at least 40 kg).<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/li>\n<li>\n<div class=\"page\" title=\"Page 2\">\n<div class=\"layoutArea\">\n<div class=\"column\">\n<p>Each film-coated tablet contains 800 mg of darunavir (as ethanolate), 150 mg of cobicistat, 200 mg of emtricitabine, and 10 mg of tenofovir alafenamide (as fumarate).<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/li>\n<li>The most common side effects (occurring in more than 1 in 10 people) are diarrhoea, nausea (feeling sick), tiredness, headache and rash. For the full list of side effects please see the\u00a0<span class=\"glossary-term\">package leaflet<\/span>.<\/li>\n<li>Symtuza was approved in Europe in September 2017,<\/li>\n<\/ul>\n<p>Please see details of individual drugs (linked above) for details of side effects and the links to the patient information and product information at the link below for full prescribing details.<\/p>\n<h2>Further information<\/h2>\n<p>The European\u00a0<em>patient information<\/em>\u00a0and detailed\u00a0<em>P<\/em><em>roduct Information<\/em>\u00a0for darunavir are available from\u00a0<a href=\"https:\/\/www.ema.europa.eu\/en\/medicines\/human\/EPAR\/symtuza\">this link<\/a>\u00a0on the European Medicines Agency (EMA) website.<\/p>\n<p>The\u00a0<em>Patient Information<\/em>\u00a0is a simplified summary: what the drug is, why it is used, results from studies and cautions including side effects.<\/p>\n<p>The\u00a0<em>Product Information<\/em>\u00a0is a detailed technical summary that you can access as a PDF file by clicking the \u2018Product Information\u2019 tab. It describes more precisely how the drug works and how it is processed by your body. This includes, for example, reported food interaction studies in terms of calories or fat content. It includes more details of the study results and a full list of side effects and drug interactions.<\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3,6,10,11],"tags":[],"class_list":["post-13594","post","type-post","status-publish","format-standard","hentry","category-arvs","category-fixed-dose-combinations","category-nukes","category-pis"],"_links":{"self":[{"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/posts\/13594","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/comments?post=13594"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/posts\/13594\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/media?parent=13594"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/categories?post=13594"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/tags?post=13594"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}