{"id":19219,"date":"2026-06-22T07:41:56","date_gmt":"2026-06-22T07:41:56","guid":{"rendered":"https:\/\/i-base.info\/guides\/?p=19219"},"modified":"2026-06-22T08:08:43","modified_gmt":"2026-06-22T08:08:43","slug":"lenacapavir-prep","status":"publish","type":"post","link":"https:\/\/i-base.info\/guides\/19219","title":{"rendered":"lenacapavir &#8211; PrEP"},"content":{"rendered":"<p>(no pic available)<br \/>\n<!--more--><em>len-a-CAP-a-veer<\/em><\/p>\n<p><strong>Lenacapavir was approved as PrEP in 2025.<\/strong><\/p>\n<p><strong>Lenacapavir is a new type of drug called a capsid inhibitor.<\/strong><\/p>\n<p>Earlier, in 2022, it was approved <a href=\"https:\/\/i-base.info\/guides\/15358\">as a treatment for HI<\/a>V multidrug resistance (MDR).<\/p>\n<ul>\n<li><strong>Dosing for PrEP<\/strong>. 2 x 300 mg oral tablets on day 1 with 2 x injections. Then 2 x 300 mg tablets on day 2.<\/li>\n<li>Lenacapavir can be taken with or without food.<\/li>\n<li><strong>Side effects.<\/strong> The main side effects are skin reactions from where the drug is injected.<\/li>\n<li><strong>Drug interactions. <\/strong>Lenacapavir has some important drug interactions. Because it is such a long-lasting drug, these interactions can continue for a long time after after the last lenacapavir injection (up to nine months). <em>Please see the full prescribing information for details of these and other interactions.<\/em><\/li>\n<li>The following drugs should NOT be taken with lenacapavir because they generally reduce levels of lenacapavir.<br \/>\n<em>Some HIV meds:<\/em> efavirenz, etravirine, nevirapine, atazanavir\/cobicistat, and tipranavir\/ritonavir.<br \/>\n<em>Some TB meds:<\/em> rifampicin, rifabutin.<br \/>\nSome anticonvulsants: carbamazepine, phenytoin, oxcarbazepine and phenobarbital.<br \/>\n<em>Some herbal supplements:<\/em> St. John\u2019s wort.<\/li>\n<li>The following drugs can be INCREASED by lenacapavir. They can sometimes be used at a lower doses.<br \/>\n<em>Some PDE-5 erectile drugs:<\/em> sildenafil (Viagra), tadalafil, vardenafil.<br \/>\n<em>Ergot derivatives:<\/em> dihydroergotamine and ergotamine.<br \/>\n<em>Some corticosteroids:<\/em> dexamethasone hydrocortisone\/cortisone.<br \/>\n<em>Some other drugs:<\/em> dioxin, midazolam, triazolam, lovastatin and simvastatin.<\/li>\n<li>There are NO interactions with oral contraceptives or with gender affirming hormones.<\/li>\n<li><strong>Resistance to PrEP.<\/strong> Drug resistance to PrEP can develop if you are late for an injection and come into contact with HIV. This is because the low levels of lenacapavir are no longer strong enough to protect against infection.<\/li>\n<li>If you decide to stop taking lenacapavir as PrEP, it is important to use other ways to protect against HIV for at least the next nine months after the date that your next injection would hvae been due.<\/li>\n<li>Lenacapavir PrEP is narketed as Yeztugo in the EU and as Yeytuo in the US.<\/li>\n<li>Lenacapavir treatment is marketed as treatment with the trade name Sunlenca in the UK.<\/li>\n<\/ul>\n<h2>Further information<\/h2>\n<p>The European\u00a0<em>patient information<\/em> and detailed <em>P<\/em><em>roduct Information<\/em> for Sunlenca are available from<a href=\"https:\/\/www.ema.europa.eu\/en\/medicines\/human\/EPAR\/sunlenca\">\u00a0this link<\/a> on the European Medicines Agency (EMA) website.<\/p>\n<p>The European\u00a0<em>patient information<\/em> and detailed <em>P<\/em><em>roduct Information<\/em> for Yeztugo are available from<a title=\" this link\" href=\"https:\/\/www.ema.europa.eu\/en\/medicines\/human\/EPAR\/yeytuo\">\u00a0this link <\/a>on the European Medicines Agency (EMA) website.<\/p>\n<p>The\u00a0<em>Patient Information<\/em>\u00a0is a simplified summary: what the drug is, why it is used, results from studies and cautions including side effects.<\/p>\n\n\n","protected":false},"excerpt":{"rendered":"<p>(no pic available)<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[21],"tags":[],"class_list":["post-19219","post","type-post","status-publish","format-standard","hentry","category-prep"],"_links":{"self":[{"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/posts\/19219","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/comments?post=19219"}],"version-history":[{"count":4,"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/posts\/19219\/revisions"}],"predecessor-version":[{"id":19225,"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/posts\/19219\/revisions\/19225"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/media?parent=19219"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/categories?post=19219"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/tags?post=19219"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}