{"id":3553,"date":"2012-08-26T09:00:38","date_gmt":"2012-08-26T09:00:38","guid":{"rendered":"http:\/\/moomango.co.uk\/guides\/?p=3553"},"modified":"2022-01-05T14:23:48","modified_gmt":"2022-01-05T14:23:48","slug":"saquinavir","status":"publish","type":"post","link":"https:\/\/i-base.info\/guides\/3553","title":{"rendered":"saquinavir"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3608\" title=\"saquinavir\" src=\"https:\/\/i-base.info\/guides\/files\/2010\/01\/saquinavir.jpg\" alt=\"saquinavir\" width=\"88\" height=\"39\" \/><br \/>\n<!--more--><em> sa-KWIN-a-veer<\/em><\/p>\n<ul>\n<li>Saquinavir (tradename Invirase) is a protease inhibitor that needs to be boosted with a separate dose of\u00a0<a href=\"https:\/\/i-base.info\/guides\/3557\">ritonavir<\/a><\/li>\n<li>Standard adult dose: 2 x 500 mg capsules, twice-daily plus a separate dose of 1 x 100 mg capsule of\u00a0<a href=\"https:\/\/i-base.info\/guides\/3557\">ritonavir<\/a>.<\/li>\n<li>Saquinavir needs to be taken with a meal or after a meal. Drug levels are reduced by 70% if taken without food.<\/li>\n<li>Side effects: changes in lipids (blood fat) which should be routinely monitored, lipodystrophy (fat accumulation) and diarrhoea.<\/li>\n<li>Other comments: saquinavir is now used less frequently in the UK because of the higher pill count and twice-daily dosing.<\/li>\n<\/ul>\n<p><strong>Further information<\/strong><\/p>\n<p>Information on\u00a0<a href=\"https:\/\/i-base.info\/guides\/side\/lipodystrophy\">lipodystrophy<\/a> from the i-Base side effects guide.<\/p>\n<p>The European\u00a0<em>patient leaflet<\/em> and detailed\u00a0<em>Product Information<\/em> for saquinavir are available from\u00a0<a href=\"https:\/\/www.ema.europa.eu\/en\/medicines\/human\/EPAR\/invirase\">this link<\/a> on the European Medicines Agency (EMA) website.<\/p>\n<p>The\u00a0<em>Patient Information<\/em> is a simplified summary: what the drug is, why it is used, results from studies and cautions including side effects.<\/p>\n<p>The\u00a0<em>Product Information<\/em> is a detailed technical summary that you can access as a PDF file by clicking the &#8216;Product Information&#8217; tab. It describes more precisely how the drug works and how it is processed by your body. This includes, for example, reported food interaction studies in terms of calories or fat content. It includes more details of the study results and a full list of side effects and drug interactions.<\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3,11],"tags":[],"class_list":["post-3553","post","type-post","status-publish","format-standard","hentry","category-arvs","category-pis"],"_links":{"self":[{"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/posts\/3553","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/comments?post=3553"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/posts\/3553\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/media?parent=3553"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/categories?post=3553"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/tags?post=3553"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}