{"id":734,"date":"2016-09-01T12:00:41","date_gmt":"2016-09-01T12:00:41","guid":{"rendered":"http:\/\/localhost.localdomain\/wpmu\/guides\/?p=734"},"modified":"2022-01-05T13:26:11","modified_gmt":"2022-01-05T13:26:11","slug":"efavirenz","status":"publish","type":"post","link":"https:\/\/i-base.info\/guides\/734","title":{"rendered":"efavirenz"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-1556\" src=\"https:\/\/i-base.info\/guides\/files\/2009\/06\/sustiva.jpg\" alt=\"Sustiva 600mg\" width=\"94\" height=\"48\" \/><br \/>\n<!--more--><em> ee-FAV-eer-enz<\/em><\/p>\n<ul>\n<li>Efavirenz (tradenames Sustiva or Stocrin in some other European countries) is a non-nucleoside reverse transcriptase inhibitor (NNRTI).<\/li>\n<li><a href=\"https:\/\/i-base.info\/guides\/starting\/nhs-changes-and-generic-drugs\">Generic formulations<\/a>\u00a0of efavirenz may be used in the UK and these will have a different brand name, a different pill size and shape and different packaging. The active ingredients will be just as effective as the original formulation.<\/li>\n<li>Standard adult doses might depend on formulations available in your country.<br \/>\n1 x \u00a0600 mg tablet, once-daily. This was the original dose.<br \/>\n<em>or<\/em><br \/>\n1 x \u00a0400 mg tablet, once-daily. Several recent studies showed that a lower 400 mg can be just as effective, with slightly fewer side effects. <a href=\"https:\/\/i-base.info\/ttfa\/section-3\/10-treatment-choices\/\">The lower dose is recommended in WHO guidelines<\/a>.<\/li>\n<li>Take before bedtime, on an empty stomach (or not with a high fat meal). A high fat meal increases drug levels of efavirenz by 60%. This increases the likelihood of side effects.<\/li>\n<li>Side effects: sleep disturbance (including nightmares), mood changes (including anxiety and depression), rash, liver toxicity, lipid changes, kidney problems. \u00a0Taking at night can help reduce side effects as you will be sleeping when drug levels are highest. A high fat meal can increase drug levels but other food is okay.<\/li>\n<li>Other notes: can now be taken during pregnancy or by women trying for a baby. Originally alternative meds were recommended.<\/li>\n<li>Efavirenz is widely used with either\u00a0<a href=\".\/746\">Truvada<\/a> or\u00a0<a href=\".\/3513\">Kivexa<\/a> in first-line combinations.<\/li>\n<li>Efavirenz is included with\u00a0<a href=\".\/3541\">tenofovir<\/a> and\u00a0<a href=\".\/3535\">FTC<\/a> in the fixed dose combination <a href=\".\/1561\">Atripla<\/a>.<\/li>\n<\/ul>\n<p><strong>Further information<\/strong><\/p>\n<p>Information on\u00a0<a href=\"https:\/\/i-base.info\/guides\/side\/cns-side-effects\">efavirenz side effects<\/a> from the i-Base side effects guide.<\/p>\n<p>The European\u00a0<em>patient information<\/em> and detailed <em>P<\/em><em>roduct Information<\/em> for efavirenz (Sustiva) from\u00a0<a href=\"https:\/\/www.ema.europa.eu\/en\/medicines\/human\/EPAR\/sustiva\">this link<\/a> at the European Medicines Agency (EMA) website. Documents for <a href=\"https:\/\/www.ema.europa.eu\/en\/search\/search?search_api_views_fulltext=sustiva\">different generic versions<\/a> are also available online.<\/p>\n<p>The\u00a0<em>Patient Information<\/em> is a simplified summary: what the drug is, why it is used, results from studies and cautions including side effects.<\/p>\n<p>The\u00a0<em>Product Information<\/em> is a detailed technical summary that you can access as a PDF file by clicking the &#8216;Product Information&#8217; tab. It describes more precisely how the drug works and how it is processed by your body. This includes, for example, reported food interaction studies in terms of calories or fat content. It includes more details of the study results and a full list of side effects and drug interactions.<\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3,9],"tags":[],"class_list":["post-734","post","type-post","status-publish","format-standard","hentry","category-arvs","category-nnrtis"],"_links":{"self":[{"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/posts\/734","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/comments?post=734"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/posts\/734\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/media?parent=734"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/categories?post=734"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/guides\/wp-json\/wp\/v2\/tags?post=734"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}