15 June 2000

Contents

Treatment alerts

• Safety warning on amprenavir oral liquid

Conference reports

• Exercise testing in HIV patients with random increased lactic acid levels: evidence for a reduced anaerobic threshold with a pattern of mitochondrial dysfunction

Antiretrovirals

• Didanosine systemic exposure in children similar with or without food, high interpatient variability suggests TDM to titrate individual dosages

• Low level HIV replication despite good virological response may explain CD4+ cell decline in a patient receiving combination nucleoside analogue therapy

Treatment strategies

• Phase III study of GM-CSF in advanced HIV disease

Women's health

• Women and HIV: is it really a biological difference?

Paediatric care

• Antiretroviral therapy improves thymic output in some HIV-infected children

Guidelines

• HIV drug resistance testing: update

Side effects

• Mitochondrial toxicities of nucleoside reverse transcriptase inhibitors

• Accelerated bone mineral loss in HIV-positive patients receiving potent antiretroviral therapy

• Irreversible renal dysfunction linked to long-term indinavir therapy

Opportunistic infections and complications

• HIV-related anal cancer incidence increased in long-term survivors

Basic science and immunology

• CD8+-cell antiviral factors not restricted to cytotoxic T cells induced during HIV

Other news

• Obiturary: Kiyoshi Kuromiya, 1943-2000

• What is Armenicum?

• Drug companies fail to conduct necessary post-marketing studies

Correspondence

• Letter: Project Inform nelfinavir potency concerns article