{"id":10208,"date":"2010-04-02T11:51:56","date_gmt":"2010-04-02T11:51:56","guid":{"rendered":"http:\/\/i-base.info\/htb\/?p=10208"},"modified":"2013-08-08T12:26:19","modified_gmt":"2013-08-08T12:26:19","slug":"fda-notice-about-drug-interactions-with-etravirine-intelence","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/10208","title":{"rendered":"FDA notice about drug interactions with etravirine (Intelence)"},"content":{"rendered":"<p><strong>FDA recently updated Intelence\u00a0(etravirine) label to include drug-drug interaction information between etravirine and fluconazole, voriconazole, lopinavir\/ritonavir tablets and<\/strong>\u00a0<strong>clopidogrel. The major changes to Section 7 Drug Interactions are summarised below.<\/strong><\/p>\n<p>In additon the magnitude of the interaction for etravirine in the presence of fluconazole, voriconazole and lopinavir\/ritonavir tablets can be found in\u00a0section 12.3 Pharmacokinetics.<\/p>\n<p><strong>Etravirine &#8211; fluconazole and voriconazole:<\/strong> Co-administration of etravirine and fluconazole or voriconazole significantly increased\u00a0etravirine exposures. The amount of safety data at these increased etravirine exposures is limited; therefore, etravirine and fluconazole or voriconazole\u00a0should be co-adminstered with caution. No dose adjustments of etravirine, fluconazole or voriconazole is needed.<\/p>\n<p><strong>Etravirine &#8211; lopinavir\/ritonavir tablets:<\/strong> Intelence and Kaletra (lopinavir\/ritonavir) tablets can be coadministered without dose\u00a0adjustment.<\/p>\n<p><strong>Etravirine &#8211; clopidogrel:<\/strong> Activation of clopidogrel to its active metabolite may be decreased when clopidogrel is co-administered with\u00a0etravirine. Alternative to clopidogrel should be considered.<\/p>\n<p>Please also refer to the full lable available online (Intelence):<br \/>\n<a href=\"http:\/\/www.accessdata.fda.gov\/scripts\/cder\/drugsatfda\">http:\/\/www.accessdata.fda.gov\/scripts\/cder\/drugsatfda<\/a><\/p>\n<p>PDF link:<br \/>\n<a href=\"http:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2010\/022187s003lbl.pdf\">http:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2010\/022187s003lbl.pdf<\/a>\u00a0 (PDF)<\/p>\n","protected":false},"excerpt":{"rendered":"<p>FDA recently updated Intelence\u00a0(etravirine) label to include drug-drug interaction information between etravirine and fluconazole, voriconazole, lopinavir\/ritonavir tablets and\u00a0clopidogrel. The major changes to Section 7 Drug Interactions are summarised below. In additon the magnitude of the interaction for etravirine in the &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-10208","post","type-post","status-publish","format-standard","hentry","category-antiretrovirals"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/10208","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=10208"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/10208\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=10208"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=10208"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=10208"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}