{"id":10513,"date":"2010-06-01T16:28:03","date_gmt":"2010-06-01T16:28:03","guid":{"rendered":"http:\/\/i-base.info\/htb\/?p=10513"},"modified":"2013-12-06T16:59:01","modified_gmt":"2013-12-06T16:59:01","slug":"effect-of-age-on-atazanavir-darunavir-raltegravir-and-etravirine","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/10513","title":{"rendered":"Effect of age on atazanavir, darunavir, raltegravir and etravirine"},"content":{"rendered":"<p><strong>www.hiv-druginteractions.org<\/strong><\/p>\n<p>Trough concentrations of atazanavir, darunavir, raltegravir and efavirenz were compared in HIV-positive volunteers, grouped according to age (A: =39, B: 40-49, C: =50 years).\u00a0 A total of 249 samples were analysed from 134 subjects (28 ATV\/r, 40 DRV\/r, 47 RAL, 19 EFV).<\/p>\n<p>Atazanavir mean trough concentrations were lower in group C than group A, but this was not statistically significant (1483 vs 1968 vs 1013 ng\/ml, A vs B vs C).\u00a0 Darunavir mean concentrations were similar across the three groups (2633 vs 3077 vs 2581 ng\/ml, A vs B vs C), as were raltegravir concentrations (210 vs 263 vs 177 ng\/ml, A vs B vs C).\u00a0 Efavirenz mean concentrations were significantly higher in group C (2950 ng\/ml) than in group A (2148 ng\/ml) or group B (2097 ng\/ml)<\/p>\n<p>No linear correlation between age and concentration was found for any drug.<\/p>\n<h2>comment<\/h2>\n<p><strong>There are few data on the metabolism of antiretroviral drugs and it may be important to study people who are older than 60, as CYP450 activity does reduce with age.<\/strong><\/p>\n<p>Ref: Tommasi C et al. Pharmacological evaluation of new antiretroviral drugs in the elderly HIV-1 infected people. Tommasi C, Nicastri E, Gallo AL, et al. 11th PK Workshop, 2010. Abstract 56.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>www.hiv-druginteractions.org Trough concentrations of atazanavir, darunavir, raltegravir and efavirenz were compared in HIV-positive volunteers, grouped according to age (A: =39, B: 40-49, C: =50 years).\u00a0 A total of 249 samples were analysed from 134 subjects (28 ATV\/r, 40 DRV\/r, 47 &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,34],"tags":[134],"class_list":["post-10513","post","type-post","status-publish","format-standard","hentry","category-conference-reports","category-pk-and-drug-interactions","tag-pk-workshop-11th-2010"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/10513","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=10513"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/10513\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=10513"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=10513"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=10513"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}