{"id":10515,"date":"2010-06-01T16:29:57","date_gmt":"2010-06-01T16:29:57","guid":{"rendered":"http:\/\/i-base.info\/htb\/?p=10515"},"modified":"2010-06-01T16:29:57","modified_gmt":"2010-06-01T16:29:57","slug":"tenofovir-may-require-closer-renal-monitoring-in-older-patients","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/10515","title":{"rendered":"Tenofovir may require closer renal monitoring in older patients"},"content":{"rendered":"<p><strong>www.hiv-druginteractions.org<\/strong><\/p>\n<p>The impact of age on tenofovir-related effects on estimated glomerular filtration rate (eGFR) were explored in a retrospective analysis of 1031 HIV-positive subjects receiving tenofovir as part of their antiretroviral regimen.\u00a0 Serum creatinine values were used to compute eGFR by the MDRD method.<\/p>\n<p>The average eGFR at baseline was 112.7 mL\/min and the median age was 43 years.<\/p>\n<p>In a univariate analysis, there was a decrease in eGFR of 0.016 mL\/min for each day of tenofovir use, an effect that persisted after controlling for age, baseline MDRD, race and gender. When age was added to a model controlling for days of tenofovir use, eGFR decreased by 0.638 mL\/min for each year increase in age.<\/p>\n<p>Individuals &gt;50 years had an average eGFR 16 ml\/min lower than individuals &lt;50 years, which reduced to 4 ml\/min lower than those &lt;50 years after controlling for baseline eGFR.\u00a0 When subjects were further stratified by age (&lt;30, 30-45, &gt;45 years), individuals aged 30-45 had an average eGFR 9.54 mL\/min less compared to those &lt;30; individuals &gt;45 had an average eGFR 11.9 mL\/min less than those &lt;30 years, after controlling for eGFR at baseline.<\/p>\n<h2>comment<\/h2>\n<p><strong>The authors of this study concluded that tenofovir may require closer monitoring in older individuals.<\/strong><\/p>\n<p>Ref: Goeddel L et al. Effect of Age on Renal Function with TDF. 11th PK Workshop, 2010. Abstract 38.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>www.hiv-druginteractions.org The impact of age on tenofovir-related effects on estimated glomerular filtration rate (eGFR) were explored in a retrospective analysis of 1031 HIV-positive subjects receiving tenofovir as part of their antiretroviral regimen.\u00a0 Serum creatinine values were used to compute eGFR &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,34,25],"tags":[134],"class_list":["post-10515","post","type-post","status-publish","format-standard","hentry","category-conference-reports","category-pk-and-drug-interactions","category-injecting-drug-users","tag-pk-workshop-11th-2010"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/10515","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=10515"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/10515\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=10515"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=10515"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=10515"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}