{"id":10529,"date":"2010-06-01T16:39:16","date_gmt":"2010-06-01T16:39:16","guid":{"rendered":"http:\/\/i-base.info\/htb\/?p=10529"},"modified":"2010-06-01T16:39:16","modified_gmt":"2010-06-01T16:39:16","slug":"atazanavir-absorption-maximised-with-food","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/10529","title":{"rendered":"Atazanavir absorption maximised with food"},"content":{"rendered":"<p><strong>www.hiv-druginteractions.org<\/strong><\/p>\n<p>The impact of food on atazanavir\/ritonavir (300\/100mg once-daily) was assessed in 12 HIV-positive volunteers. When given without food, atazanavir AUC, Cmax and Ctrough decreased by 41%, 32% and 53%, respectively. Ritonavir AUC and Ctrough decreased by 26% and 53%; Cmax increased by 4%. One patient had atazanavir Ctrough below target (&lt;150 ng\/mL), but no patients showed evidence of virologic failure. <\/p>\n<h2><strong>comment<\/strong><\/h2>\n<p> <strong>This study indicates that food maximises the absorption of atazanavir and supports the recommendation to take atazanavir\/ritoanavir with food.<\/strong><\/p>\n<p>Ref: Giguerre P et al. The effect of food on the pharmacokinetics of atazanavir\/ritonavir 300\/100mg daily in HIV-infected patients. 11th PK Workshop, 2010. Abstract 30. <\/p>\n<div><span> <\/span><\/div>\n","protected":false},"excerpt":{"rendered":"<p>www.hiv-druginteractions.org The impact of food on atazanavir\/ritonavir (300\/100mg once-daily) was assessed in 12 HIV-positive volunteers. When given without food, atazanavir AUC, Cmax and Ctrough decreased by 41%, 32% and 53%, respectively. Ritonavir AUC and Ctrough decreased by 26% and 53%; &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,34],"tags":[134],"class_list":["post-10529","post","type-post","status-publish","format-standard","hentry","category-conference-reports","category-pk-and-drug-interactions","tag-pk-workshop-11th-2010"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/10529","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=10529"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/10529\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=10529"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=10529"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=10529"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}