{"id":10596,"date":"2003-02-01T09:12:57","date_gmt":"2003-02-01T09:12:57","guid":{"rendered":"http:\/\/i-base.info\/htb\/?p=10596"},"modified":"2014-05-28T16:56:32","modified_gmt":"2014-05-28T16:56:32","slug":"navigating-resistance-pathways","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/10596","title":{"rendered":"Navigating resistance pathways"},"content":{"rendered":"<p><strong>Daniel Kuritzkes<br \/>\n<\/strong>from The AIDS Reader<\/p>\n<p><strong>One of the most daunting challenges facing HIV-treating clinicians is the persistent spectre of treatment failure in their patients.<\/strong><\/p>\n<p>There are several factors involved in the development of treatment failure in HIV-infected patients including preexisting resistant viral variants; the potency of the drugs used (and thus the barrier to resistance of each drug and the regimen as a whole); patient-specific factors, such as adherence; and pharmacologic factors. Host immunologic status is also important because the more advanced the disease is, the less likely it is that a complete response to antiretroviral therapy will occur.<\/p>\n<p>These factors, when combined, can result in incomplete suppression of viral replication and, in the setting of persistent viral replication, a greater opportunity for drug resistance mutations to emerge. The emergence of these mutations initiates a cycle of less treatment efficacy, less viral suppression, more viral replication, and broader cross-resistance, which cycles back to less treatment efficacy and ultimately leads to failure of the regimen.<\/p>\n<p>Full text at:<a href=\"http:\/\/www.medscape.com\/viewarticle\/442763\"><br \/>\nhttp:\/\/www.medscape.com\/viewarticle\/442763<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Daniel Kuritzkes from The AIDS Reader One of the most daunting challenges facing HIV-treating clinicians is the persistent spectre of treatment failure in their patients. There are several factors involved in the development of treatment failure in HIV-infected patients including &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[30],"tags":[],"class_list":["post-10596","post","type-post","status-publish","format-standard","hentry","category-on-the-web"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/10596","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=10596"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/10596\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=10596"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=10596"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=10596"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}