{"id":10646,"date":"2003-02-01T10:23:35","date_gmt":"2003-02-01T10:23:35","guid":{"rendered":"http:\/\/i-base.info\/htb\/?p=10646"},"modified":"2014-05-28T16:48:50","modified_gmt":"2014-05-28T16:48:50","slug":"breadth-of-memory-ctl-response-against-hiv-associated-with-immune-control","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/10646","title":{"rendered":"Breadth of memory CTL response against HIV associated with immune control"},"content":{"rendered":"

The number of HIV antigens recognised by memory cytotoxic T lymphocytes (CTL) is a major correlate of viral control and tends to decrease with the duration of infection, study results suggest. According to the French investigators, these findings underscore the importance of incorporating a wide range of HIV antigens into therapeutic vaccines.<\/strong><\/p>\n

For their prospective study, Dr Yves Riviere, of Institut Pasteur in Paris, and his colleagues in the IMMUNOCO Study Group enrolled 148 HIV-infected patients between 1991 and 1992, prior to the advent of highly active antiretroviral therapy (HAART).<\/p>\n

They evaluated blood samples annually until the end of 1996 for cytotoxic responses to seven antigens. One hundred and twenty-two subjects were assessed for viral load at least once during follow-up. Over the course of the study, none of the patients received more than two antiretroviral agents.<\/p>\n

Approximately 75% of the subjects exhibited CTL responses against one or more proteins during the trial period, the authors report in the 6 December issue of AIDS. At baseline, 23% of subjects had CTL cells that recognised none of the proteins, while 8% had cells that recognised one protein, 32% had cells that recognised two, and 17% recognised three. None of the target antigens tested on its own correlated with disease progression.<\/p>\n

The number of recognised antigens was associated with viral load at baseline (p < 0.05) and declined at an average of 0.14 protein per year. However, the rate of reduction increased to one protein per year when opportunistic infections were present.<\/p>\n

Dr Riviere\u2019s group theorises that there is \u201ca progressive exhaustion in the CTL capacity to proliferate and\/or to kill specific target cells.\u201d<\/p>\n

The diversity of CTL response was negatively associated with CD8 cell counts, but not with CD4 counts. The authors suggest that \u201cCD4 T-helper cell depletion does not directly influence the loss of diversity in HIV-specific CTL responses.\u201d<\/p>\n

In addition to the implications regarding vaccination strategies, the research team concludes that the study findings provide \u201cnew end-points for immune-based therapeutic strategies aimed at restoring a strong and protective immunity against HIV in individuals receiving HAART.\u201d<\/p>\n

Reference:<\/p>\n

Chouquet C, Autran B, Gomard E et al. Correlation between breadth of memory HIV-specific cytotoxic T cells, viral load and disease progression in HIV infection. AIDS 2002 Dec 6;16(18):2399-407 http:\/\/www.ncbi.nlm.nih.gov:80\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12461413&dopt=Abstract<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

The number of HIV antigens recognised by memory cytotoxic T lymphocytes (CTL) is a major correlate of viral control and tends to decrease with the duration of infection, study results suggest. According to the French investigators, these findings underscore the …<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[15],"tags":[],"class_list":["post-10646","post","type-post","status-publish","format-standard","hentry","category-basic-science-and-immunology"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/10646","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=10646"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/10646\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=10646"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=10646"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=10646"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}