{"id":10808,"date":"2003-03-01T10:52:59","date_gmt":"2003-03-01T10:52:59","guid":{"rendered":"http:\/\/i-base.info\/htb\/?p=10808"},"modified":"2017-02-11T02:45:23","modified_gmt":"2017-02-11T02:45:23","slug":"review-of-trials-shows-testosterone-increases-lean-body-mass-and-is-most-effective-when-given-intramuscularly","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/10808","title":{"rendered":"Review of trials shows testosterone increases lean body mass, and is most effective when given intramuscularly"},"content":{"rendered":"<p><strong>Graham McKerrow, HIV i-Base<\/strong><\/p>\n<p><strong>A review of randomised, placebo-controlled trials concludes that testosterone therapy increases lean body mass more than placebo in HIV-positive patients with wasting. And the researchers at St Bartholomew\u2019s Hospital in London also conclude that the increase is even greater if the therapy is given intramuscularly.<\/strong><\/p>\n<p>Anthony Kong and colleagues report that eight trials met the inclusion criteria and 417 randomised patients were included. Only six trials used lean body mass, fat-free mass, or body cell mass as outcome measures and meta-analysis of these showed a difference in lean body mass between the testosterone group and the placebo group of 1.22kg for the random effect model and 0.51kg for fixed effect.<\/p>\n<p>The researchers draw attention to the fact that the difference was much greater in three trials that used the intramuscular route: 3.34kg in the post hoc analysis.<\/p>\n<p>All eight trials included total body weight as an outcome measure, the meta-analysis of which showed a difference of 1.04kg by random effect and 0.63kg for fixed effect models. The incidence of adverse effects was similar in both groups.<\/p>\n<p>The researchers warn that the study is limited by the small numbers and heterogeneity of the population, but nonetheless they write: \u201cTestosterone therapy may be considered in patients with HIV wasting syndrome to reverse muscular loss, but there is a concern about the adverse metabolic effects of long-term testosterone administration and long-term follow-up for these patients is needed.\u201d<\/p>\n<p>Reference:<\/p>\n<p>Kong A, Edmonds P. Testosterone therapy in HIV wasting syndrome: systematic review and meta-analysis. Lancet Infect Dis 2002 Nov;2(11):692-9<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov:80\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=12409050&amp;dopt=Abstract\">http:\/\/www.ncbi.nlm.nih.gov:80\/entrez\/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=12409050&amp;dopt=Abstract<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Graham McKerrow, HIV i-Base A review of randomised, placebo-controlled trials concludes that testosterone therapy increases lean body mass more than placebo in HIV-positive patients with wasting. And the researchers at St Bartholomew\u2019s Hospital in London also conclude that the increase &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[27],"tags":[],"class_list":["post-10808","post","type-post","status-publish","format-standard","hentry","category-weight-diabetes-metabolic-complications"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/10808","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=10808"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/10808\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=10808"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=10808"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=10808"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}