Where Now for Trizivir? – Role of the Triple-NRTI Pill Post-ACTG 5095<\/strong> Long-term complications of nucleoside reverse transcriptase inhibitor therapy<\/strong> Toxic effects of nucleoside reverse transcriptase inhibitors on the liver<\/strong> From: AIDS Reader Where Now for Trizivir? – Role of the Triple-NRTI Pill Post-ACTG 5095 Graeme J. Moyle, MD, MBBS Triple NRTI therapy should be avoided as sole initial therapy. Histoplasmosis in a patient with AIDS http:\/\/mp.medscape.com\/cgi-bin1\/DM\/y\/hb860F74sn0D1P0Faxk0AS Long-term complications of …<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[30],"tags":[],"class_list":["post-11324","post","type-post","status-publish","format-standard","hentry","category-on-the-web"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/11324","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=11324"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/11324\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=11324"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=11324"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=11324"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\nGraeme J. Moyle, MD, MBBS
\nTriple NRTI therapy should be avoided as sole initial therapy.
\nHistoplasmosis in a patient with AIDS
\n http:\/\/mp.medscape.com\/cgi-bin1\/DM\/y\/hb860F74sn0D1P0Faxk0AS<\/a><\/p>\n
\nDouglas Dieterich MD
\nReview of the major long-term complications associated with NRTIs: hyperlactatemia and lactic acidosis\/hepatic steatosis, other hepatotoxicities, pancreatitis, lipodystrophy\/lipoatrophy, neuropathy, and haematologic toxicities.
\n http:\/\/mp.medscape.com\/cgi-bin1\/DM\/y\/hb860F74sn0D1P0FaxI0AT<\/a><\/p>\nFrom: American Journal of Clinical Pathology<\/h2>\n
\nThe authors demonstrate that NRTI-induced toxic effects in the liver may occur as indolent nonspecific disease with variable histologic features and emphasises the diagnostic value of electron microscopy, particularly when diffuse steatosis is absent.
\n http:\/\/mp.medscape.com\/cgi-bin1\/DM\/y\/hb860F74sn0D1P0Faxj0AR<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"