{"id":11617,"date":"2003-09-01T06:06:02","date_gmt":"2003-09-01T06:06:02","guid":{"rendered":"http:\/\/i-base.info\/htb\/?p=11617"},"modified":"2014-05-27T11:44:12","modified_gmt":"2014-05-27T11:44:12","slug":"dual-boosted-pis-in-salvage-therapy","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/11617","title":{"rendered":"Dual boosted PIs in salvage therapy"},"content":{"rendered":"<p><strong>Several studies reported results from dual boosted PIs in salvage setting that included additional background nucleosides.<\/strong><\/p>\n<h2>Lopinavir\/r with amprenavir requires additional ritonavir boosting<\/h2>\n<p>In France, Raguin and colleagues presented 48 week results of the PUZZLE 1 study (ANRS 104) which looked at an additional 200mg\/day ritonavir added to different combinations that included lopinavir\/r and amprenavir (with NRTIs) in heavily experienced patients on current failing therapy. [5] While the resistance profile of these two drugs make the combination of interest, both lopinavir and amprenavir levels drop when used together.<\/p>\n<p>Thirty-seven of 40 patients started treatment with median baseline viral load and CD4 of 4.7 log and 207 cells\/mm3 respectively. Baseline resistance profile (all median) included seven PI mutations and a phenotypic resistance index of 9.7 for LPV and 2.6 for APV. Average number of antiretrovirals taken prior to randomisation was 7.7.<\/p>\n<p>Twenty-six-week data presented at last year\u2019s ICAAC showed that the additional ritonavir produced viral load reductions of \u20132.5 compared to \u20131.4 without. Twice as many patients achieved viral load &lt; 50 copies\/ml (62% versus 32%). This difference continued to remain significant for the additional ritonavir group with median viral load reduction at week 52 of \u20132.0 log compared to \u20131.1 (p=0.05). Undetectable viral load &lt;50 copies was achieved by 39% (7\/18) compared to 11% (2\/18) in the two groups respectively (P=0.12).<\/p>\n<p>Discontinuation of at least one of the two PIs (APV or LPV) occurred in six and eight patients and grade IV adverse events occurred in seven and 10 patients, respectively.<\/p>\n<p>Reference:<\/p>\n<p>Raguin G, Chene G, Morand-Joubert L et al. Salvage therapy with lopinavir\/r (LPV\/r), amprenavir (APV) \u00b1 an additional boost with ritonavir (RTV): 1-year results of PUZZLE-1 \u2013 ANRS 104 study. 2nd IAS Conference on HIV Pathogenesis and Treatment, 13-16 July 2003, Paris.\u00a0Abstract 585.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Several studies reported results from dual boosted PIs in salvage setting that included additional background nucleosides. Lopinavir\/r with amprenavir requires additional ritonavir boosting In France, Raguin and colleagues presented 48 week results of the PUZZLE 1 study (ANRS 104) which &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,3],"tags":[90],"class_list":["post-11617","post","type-post","status-publish","format-standard","hentry","category-conference-reports","category-antiretrovirals","tag-ias-2nd-2003"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/11617","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=11617"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/11617\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=11617"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=11617"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=11617"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}