{"id":11655,"date":"2003-09-01T07:12:55","date_gmt":"2003-09-01T07:12:55","guid":{"rendered":"http:\/\/i-base.info\/htb\/?p=11655"},"modified":"2014-05-27T11:33:12","modified_gmt":"2014-05-27T11:33:12","slug":"5th-international-workshop-on-adverse-drug-reactions-and-lipodystrophy","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/11655","title":{"rendered":"5th International Workshop on Adverse Drug Reactions and Lipodystrophy, 8-11 July 2003, Paris"},"content":{"rendered":"<p><strong>Articles included:<\/strong><\/p>\n<ul>\n<li><a href=\"https:\/\/i-base.info\/htb\/11653\"> Underlying mechanisms: adipocytes and cytokines<\/a><\/li>\n<li><a href=\"https:\/\/i-base.info\/htb\/11651\">More mitochondrial DNA depletion<\/a><\/li>\n<li><a href=\"https:\/\/i-base.info\/htb\/11646\">IMT and cardiovascular risk<\/a><\/li>\n<li><a href=\"https:\/\/i-base.info\/htb\/11646\"> Reduced bone mineral density in HIV-positive women<\/a><\/li>\n<li><a href=\"https:\/\/i-base.info\/htb\/11642\"> Rosiglitazone reversed peripheral lipoatrophy in HIV-patients with insulin resistance<\/a><\/li>\n<li><a href=\"https:\/\/i-base.info\/htb\/11639\">Additional benefits of exercise with metformin<\/a><\/li>\n<li><a href=\"https:\/\/i-base.info\/htb\/11637\"> Mitochondrial toxicity with AZT and d4T \u2013 and benefits of switch to abacavir<\/a><\/li>\n<li><a href=\"https:\/\/i-base.info\/htb\/11635\"> Facial fat loss \u2013 measuring and treatment<\/a><\/li>\n<li><a href=\"https:\/\/i-base.info\/htb\/11633\"> Uridine treatment for mitochondrial toxicity<\/a><\/li>\n<li><a href=\"https:\/\/i-base.info\/htb\/11631\"> Breast enlargement in men and testosterone treatment<\/a><\/li>\n<li><a href=\"https:\/\/i-base.info\/htb\/11629\">Severe efavirenz psychotic events<\/a><\/li>\n<li><a href=\"https:\/\/i-base.info\/htb\/11627\"> Treatment interruption can improve lipodystrophy<\/a><\/li>\n<\/ul>\n<p>References:<\/p>\n<p>Unless otherwise stated, all abstracts refer to the programme and abstracts from the 5th International Workshop on Adverse Drug Reactions and Lipodystrophy in HIV, 8-11 July 2003, Paris and are published in Antiviral Therapy Volume 8 issue 4.<\/p>\n<ol>\n<li>Capeau J, Caron M, Auclair M et al \u2013 Effects of NRTI on differentiation, response to insulin and apoptosis in cultured adipocytes. 2nd IAS Conference on HIV Pathogenesis and Treatment, 13\u201316 July, Paris. Abstract 206.<\/li>\n<li>Yamauchi T &#8211; The roles and mechanisms of adipocytokines in insulin resistance. Abstract P3.<\/li>\n<li>Khatami H, Mulligan K, Lo JC et al \u2013 Role of adipocytokines and body fat distribution in insulin resistance in HIV infection. Abstract 44<\/li>\n<li>Frayn K &#8211; Adipose tissue and insulin resistance. Abstract P2.<\/li>\n<li>Deveaud C, Beauvoit B, Rogoulet M \u2013 Effects of the treatment by nucleoside reverse transcriptase inhibitors on mitochondrial function of superficial and deep adipose tissues of rats. Abstract 50.<\/li>\n<li>Maisonneuve C, Begriche K &#8211; Effects of AZT and d4T on ketone bodies and lipids in mice: possible role of beta-aminoisobutyric acid, a catabolite of thymine. Abstract 20.<\/li>\n<li>Flint OP, Mulvey R, Elosua C et al \u2013 The effect of tenofovir, zidovudine and stavudine on adipocyte mitochondrial DNA, viability and lipid metabolism. Abstract 65.<\/li>\n<li>Caron M, Auclair M, Kornprobst M et al &#8211; Effects of NRTI on differentiation, response to insulin and apoptosis in cultured adipocytes. Abstract 10.<\/li>\n<li>Capeau J, Bastard JP, Cervera P et al &#8211; Increased IL-6 and TNF expression is related to increased apoptosis and decreased differentiation in adipose tissue from patients with HIV-related lipoatrophy. Abstract 9.<\/li>\n<li>Nolan D, Hammond E, McKinnon E et al &#8211; Subcutaneous fat tissue mitochondrial DNA depletion and adipose toxicity are strongly associated with nucleoside reverse transcriptase inhibitor (NRTI) therapy in HIV-infected patients. Abstract 18.<\/li>\n<li>Lopez S, Miro O, Martinez E et al \u2013 Does HIV infection itself have any effect on mitochondrial DNA content? Abstract 54.<\/li>\n<li>Tebas P, Mondy K, De Ronde A et al \u2013 Effects of different antiretroviral treatments on mitochondrial DNA levels in PBMCs of HIV-infected patients. Abstract 60.<\/li>\n<li>Shahmanesh M, Das S, Stolinski M et al &#8211; Effects of HIV infection, antiviral treatment and body fat changes on VLDL-apolipoprotein-B metabolism. Abstract 3.<\/li>\n<li>Mercie P, Thiebaut R et al &#8211; Carotid intima-media thickness is moderately increased over time in HIV-1-infected patients. Abstract 2.<\/li>\n<li>Hsue P, Lo J, Franklin A et al \u2013 Predictors of atherosclerosis and atherosclerotic progression in patients with HIV: the role of traditional and immunological risk factors. Abstract 35<\/li>\n<li>Grinspoon S, Dolan SE, Huang JS et al \u2013 Reduced bone mineral density in HIV-infected women. Abstract 24.<\/li>\n<li>Hadigan C, Yawetz S, Thomas A et al &#8211; A randomised, double-blind, placebo-controlled study of rosiglitazone for patients with HIV lipodystrophy. Abstract 12.<\/li>\n<li>Oette M, Gobels K, Kurowski M et al \u2013 Rosiglitazone treatment of HIV-associated lipodystrophy syndrome: impact on the bioavailability of antiviral compounds. Abstract115.<\/li>\n<li>Driscoll S, Meininger G, Lareau M et al &#8211; Effects of exercise training and metformin on body composition and cardiovascular indices in HIV-infected patients. Abstract 4.<\/li>\n<li>Carr A, Martin A, Ringland C et al &#8211; Long term changes in lipodystrophy after switching from thymidine nucleoside analogues to abacavir. Abstract 16.<\/li>\n<li>Raghavan S, Shlay JC et al &#8211; Rates of change in body composition among antiretroviral-na\u00efve HIV-infected patients randomised to a didanosine\/stavudine versus abacavir\/lamivudine containing regimen in the Flexible Initial Retrovirus Suppressive Therapies (FIRST) study (CPCRA 058). Abstract 13.<\/li>\n<li>Frize G, Hughes A, Scullard G et al \u2013 Attitudes and perceptions of patients with facial lipoatrophy before and after intervention using polylactic acid. Abstract 110.<\/li>\n<li>Guaraldi G, De Fazio D, Orlando G et al &#8211; Fat accumulation of the cheeks after autologous fat transfer for treating facial wasting in HIV-related lipodystrophy. Abstract 81.<\/li>\n<li>Walker U, Koch E, Venhoff N et al &#8211; Uridine prevents and treats mtDNA depletion by NRTI pyrimidine analogues and fully restores mitochondrial function. Abstract 19.<\/li>\n<li>Garcia M, Martinez E, Domingo P et al \u2013 Breast enlargement in male HIV-infected patients. Abstract 82.<\/li>\n<li>Allin M, Reeves I, Everal I et al \u2013 Frequency of serious psychiatric adverse events with efavirenz. Abstract 129.<\/li>\n<li>Trenado E &#8211; Lipodystrophic body changes and quality of life. Clinical management workshop.<\/li>\n<li>Martinez E, Milenkovic A, Vidal S et al \u2013 Impact of structured treatment interruption on body composition of chronically infected patients: preliminary one year results. Abstract 88.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Articles included: Underlying mechanisms: adipocytes and cytokines More mitochondrial DNA depletion IMT and cardiovascular risk Reduced bone mineral density in HIV-positive women Rosiglitazone reversed peripheral lipoatrophy in HIV-patients with insulin resistance Additional benefits of exercise with metformin Mitochondrial toxicity with &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,27],"tags":[126,12],"class_list":["post-11655","post","type-post","status-publish","format-standard","hentry","category-conference-reports","category-weight-diabetes-metabolic-complications","tag-lipo-5th-2003","tag-conference-index"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/11655","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=11655"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/11655\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=11655"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=11655"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=11655"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}