{"id":11746,"date":"2003-10-01T11:46:55","date_gmt":"2003-10-01T11:46:55","guid":{"rendered":"http:\/\/i-base.info\/htb\/?p=11746"},"modified":"2014-05-27T11:04:16","modified_gmt":"2014-05-27T11:04:16","slug":"only-time-with-hiv-infection-and-not-specific-antiretroviral-therapy-is-associated-with-decreased-bone-mineral-density","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/11746","title":{"rendered":"Only time with HIV infection and not specific antiretroviral therapy is associated with decreased bone mineral density"},"content":{"rendered":"<p><strong>HIVandHepatitis.com<\/strong><\/p>\n<p><strong>The aim of this cross-sectional analytical study was to describe the alterations in the bone metabolism of HIV-seropositive patients and evaluate the effects of antiretroviral therapies. Published in the September 5, 2003 issue of AIDS, this cross-sectional analytical study was undertaken by researchers at the Medical Science School of the National University of Cordoba and Rawson Hospital, Cordoba, Argentina.<\/strong><\/p>\n<p>A total of 142 subjects (113 male, 29 female), aged 20-45 years were divided into four groups: group A, 33 HIV-seropositive antiretroviral-naive patients; group B1, 36 HIV-seropositive patients on antiviral therapy for over one year, without protease inhibitors (PI); group B2, 42 HIV-seropositive patients on combined therapy containing PI for over one year; and group C, 15 healthy, HIV-seronegative subjects.<\/p>\n<p>Bone mineral density (BMD) was determined by dual energy X-ray absorptiometry in total body, lumbar spine and proximal femur; and evaluation of serum osteocalcin, d-pyridinoline, parathyroid hormone (THP), calcium and phosphate, and urine calcium.<\/p>\n<p>BMD was significantly lower in HIV-seropositive patients in comparison with healthy controls, in all sites studied. However, no statistical differences were observed among all groups of HIV-infected patients, independently of the antiretroviral therapy.<\/p>\n<p>There was a significantly higher occurrence of osteopaenia and osteoporosis in HIV-infected patients in comparison with controls (P &lt; 0.0001), with no differences among treatment-naive patients and either of the treatment groups. Bone formation and resorption markers were similar among all studied groups. There was a significant correlation in all bone sites between time of infection and BMD (P &lt; 0.02).<\/p>\n<p>BMD was significantly lower in HIV-seropositive patients in comparison with controls in lumbar spine, proximal femur and total body, without significant differences among treatment-naive patients and either of the treatment groups.<\/p>\n<p>Only time with HIV infection and not specific therapy was associated with BMD decreases.<\/p>\n<p>Source: HIVandHepatitis.com<br \/>\n<a href=\"http:\/\/www.hivandhepatitis.com\/recent\/toxicities\/bone\/082503c.html\">http:\/\/www.hivandhepatitis.com\/recent\/toxicities\/bone\/082503c.html<\/a><\/p>\n<p>Reference:<\/p>\n<p>Bruera D et al. Decreased bone mineral density in HIV-infected patients is independent of antiretroviral therapy. AIDS 17(13): 1917-1923. September 5, 2003.<\/p>\n<p>\u00a9 Copyright 2002 by HIV and Hepatitis.com. All Rights Reserved. Reproduction for personal or educational use is encouraged and does not require permission. Written permission is required to re-print copyrighted articles but is almost always granted (email <a href=\"mailto:publisher@HIVandHepatitis.com\">publisher@HIVandHepatitis.com<\/a>).<\/p>\n","protected":false},"excerpt":{"rendered":"<p>HIVandHepatitis.com The aim of this cross-sectional analytical study was to describe the alterations in the bone metabolism of HIV-seropositive patients and evaluate the effects of antiretroviral therapies. Published in the September 5, 2003 issue of AIDS, this cross-sectional analytical study &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-11746","post","type-post","status-publish","format-standard","hentry","category-side-effects"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/11746","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=11746"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/11746\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=11746"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=11746"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=11746"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}