{"id":13819,"date":"2010-08-26T12:22:32","date_gmt":"2010-08-26T12:22:32","guid":{"rendered":"http:\/\/i-base.info\/htb\/?p=13819"},"modified":"2012-07-27T10:08:04","modified_gmt":"2012-07-27T10:08:04","slug":"quadrivalent-hpv-vaccine-reduces-genital-lesions-and-hpv-acquisition-in-men","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/13819","title":{"rendered":"Quadrivalent HPV vaccine reduces genital lesions and HPV acquisition in men"},"content":{"rendered":"<p><strong>Simon Collins, HIV i-Base<\/strong><\/p>\n<p>Heiko Jensen from Praxis presented the results of a large randomised placebo-controlled study in over 4000 men in 18 countries of the Merck quadrivalent HPV vaccine (active against types 6\/11\/16\/18) that was initially studied and approved for use in women. Participants needed to be HIV-negative, HPV seronegative, HPV PCR negative, without genital lesions and to have had fewer than seven sexual partners.<\/p>\n<p>The primary efficacy objective was to demonstrate whether the vaccine reduces the incidence of external genital lesions (EGL) related to HPV6\/11\/16 or 18.<\/p>\n<p>After approximately two years follow-up, in a per protocol analysis, there were 3 cases of lesions in the active arm vs 31 in the placebo group. This produced efficacy rates of 65.5% (95% CI: 45.8, 78.6) in the ITT and 90.4% (95% CI: 69.2, 98.1) in the per protocol analyses.<\/p>\n<p>The majority of EGL observed were condylomata acuminata; no cases of penile\/perianal\/perineal intraepithelial neoplasia were observed, though this was a period, follow-up in the study will extend to ten years.<\/p>\n<p>For other endpoints, the rapporteur report noted 89% efficacy in preventing condyloma, 75% efficacy in preventing high grade anal intra-epithelial neoplasia (AIN 2 or more), 78% efficacy in preventing a combined endpoint of AIN or anal cancer over all, and 86% efficacy against \u0093persistent infection\u0094 (defined by positive DNA PCR on 2 samples 4 months apart).<\/p>\n<p>References:<\/p>\n<ol>\n<li>Jessen H et al. Quadrivalent HPV vaccine efficacy against HPV 6\/11\/16\/18 infection and disease in men. 18th IAS Conference, 18\u009623<br \/>\nJuly 2010, Vienna. Late breaker oral abstract THLBB0101. <a href=\"http:\/\/pag.aids2010.org\/Abstracts.aspx?AID=17491\">http:\/\/pag.aids2010.org\/Abstracts.aspx?AID=17491<\/a><\/li>\n<li>Garland et al. Quadrivalent vaccine<br \/>\nagainst Human Papillomavirus to prevent anogenital diseases. N Engl J Med 2007; 356:1928-1943 <a href=\"http:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa061741\">http:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa061741<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Simon Collins, HIV i-Base Heiko Jensen from Praxis presented the results of a large randomised placebo-controlled study in over 4000 men in 18 countries of the Merck quadrivalent HPV vaccine (active against types 6\/11\/16\/18) that was initially studied and approved &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,10,42],"tags":[153],"class_list":["post-13819","post","type-post","status-publish","format-standard","hentry","category-conference-reports","category-transmission-and-prevention","category-vaccines-and-microbicides","tag-aids-18th-vienna-2010"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/13819","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=13819"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/13819\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=13819"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=13819"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=13819"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}