{"id":1397,"date":"2009-04-20T10:29:49","date_gmt":"2009-04-20T10:29:49","guid":{"rendered":"http:\/\/localhost.localdomain\/wpmu\/htb\/?p=1397"},"modified":"2013-08-16T14:33:00","modified_gmt":"2013-08-16T14:33:00","slug":"croi-effect-of-substance-abuse-on-art-pharmacokinetics","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/1397","title":{"rendered":"Effect of substance abuse on ART pharmacokinetics"},"content":{"rendered":"<p><strong>hiv-druginteractions.org<\/strong><\/p>\n<p><strong>This study looked at a group of 275 patients, 47% of whom were active users of at least one substance (heroin 2%; cocaine 7%; marijuana 13%; tobacco 43%; alcohol 22%; prescription opioids 14%). <\/strong><\/p>\n<p>It was found that a significantly higher proportion of substance users had antiretroviral trough concentrations below the therapeutic range (23% vs 9%, p=0.048). The proportion of patients with an unfavourable treatment outcome (HIV RNA &gt;75 copies\/ml) was significantly higher in the substance user group than in the non-user group (40% vs 28%, p=0.044). However, when adjusted for race, substance abuse was no longer associated with virological response.<\/p>\n<p>Reference:<\/p>\n<p>Ma Q, et al. Comparison of ART pharmacokinetics and clinical monitoring parameters in HIV-infected patients with and without substance abuse. 16th CROI, Montreal, 2009. Abstract 698.<br \/>\n<a href=\"http:\/\/www.retroconference.org\/2009\/Abstracts\/35802.htm\">http:\/\/www.retroconference.org\/2009\/Abstracts\/35802.htm<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>hiv-druginteractions.org This study looked at a group of 275 patients, 47% of whom were active users of at least one substance (heroin 2%; cocaine 7%; marijuana 13%; tobacco 43%; alcohol 22%; prescription opioids 14%). It was found that a significantly &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[63],"class_list":["post-1397","post","type-post","status-publish","format-standard","hentry","category-conference-reports","tag-croi-2009"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/1397","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=1397"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/1397\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=1397"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=1397"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=1397"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}