{"id":14807,"date":"2011-04-01T15:00:12","date_gmt":"2011-04-01T15:00:12","guid":{"rendered":"http:\/\/i-base.info\/htb\/?p=14807"},"modified":"2011-04-01T15:00:12","modified_gmt":"2011-04-01T15:00:12","slug":"hcv-reinfection-rates-in-hiv-positive-gay-men","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/14807","title":{"rendered":"HCV reinfection rates in HIV-positive gay men"},"content":{"rendered":"<p><strong>Simon Collins, HIV i-Base<\/strong><\/p>\n<p>Several research groups that highlighted the increased rates of sexual HCV transmission in HIV-positive gay men have also included reports of reinfection with HCV after achieving successful HCV treatment.<\/p>\n<p>In a cohort of 62 HIV-positive men from the Netherlands, Thomas and colleagues compared HCV genetic samples obtained during initial acute HCV infection to the last available sample (median time 2.1 years; IQR 0.5\u00963.8). Of the 58 patient with successful samples expanded in the NS5B gene, HCV genotype switches were found in 10 people: genotype 1a to 4d (n=4), 4d to 1a (n=3), 1a to 3a (n=1), 3a to 1a (n=1) and 4a to 4d (n=1). [1]<\/p>\n<p>HVR1 sequences (which allow for clade comparison within genotypes) were successfully expanded in 37\/48 people without a genotype switch and showed that reinfection with the same genotype occurred in two people (one with genotype-1a and one genotype-4d).<\/p>\n<p>The researchers concluded that \u0093reinfection occurred frequently in this group of patients:  in 12 of 58 (21%) a different virus was detected at the end of follow-up than the initial virus\u0094. The study also suggested that partial immunity against re-infection with the same genotype might exist in HIV-positive people.<\/p>\n<p>In a second poster from the same group, Femke Lambers and colleagues looked at rate of HCV reinfection in HIV-positive men in Amsterdam who had achieved sustained virological responses (SVR) to HCV treatment. Of 26 people who became PCR-negative, maintained for two months, six were reinfected.  One person was excluded from the analysis because his genotype was unknown. Total follow-up time in these 25 people was 35.5 years; median follow-up 1.1 years (IQR 0.4 to 1.9). The median time between test intervals was 2.9 months (IQR 1.6 to 4.1).<\/p>\n<p>This led to an incidence of HCV reinfection in this group of 16.9 \/100 person-years (95%CI 6.9 to 35.2), which is approximately 10-fold higher that HCV infection rates in HIV-positive men who have not previously been infected with HCV.<\/p>\n<p>References:<\/p>\n<ol>\n<li>Thomas X et al. Frequent HCV re-infection in HIV+ MSM. Poster abstract 912.<br \/>\n<a href=\"http:\/\/www.retroconference.org\/2011\/Abstracts\/42120.htm\">http:\/\/www.retroconference.org\/2011\/Abstracts\/42120.htm<\/a><\/li>\n<li>Lambers F et al. High incidence rate of HCV reinfection after treatment of acute HCV infection in HIV+ MSM: Amsterdam. Poster abstract 958.<br \/>\n<a href=\"http:\/\/www.retroconference.org\/2011\/Abstracts8888\/42537.htm\">http:\/\/www.retroconference.org\/2011\/Abstracts8888\/42537.htm<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Simon Collins, HIV i-Base Several research groups that highlighted the increased rates of sexual HCV transmission in HIV-positive gay men have also included reports of reinfection with HCV after achieving successful HCV treatment. In a cohort of 62 HIV-positive men &hellip;<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[65],"class_list":["post-14807","post","type-post","status-publish","format-standard","hentry","category-conference-reports","tag-croi-2011"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/14807","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=14807"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/14807\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=14807"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=14807"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=14807"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}