{"id":15900,"date":"2011-12-01T11:36:33","date_gmt":"2011-12-01T11:36:33","guid":{"rendered":"http:\/\/i-base.info\/htb\/?p=15900"},"modified":"2011-12-01T11:36:33","modified_gmt":"2011-12-01T11:36:33","slug":"cd4-count-200-independently-associated-with-5-fold-increased-risk-of-fracture","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/15900","title":{"rendered":"CD4 count <200 independently associated with 5-fold increased risk of fracture"},"content":{"rendered":"<p><strong>Simon Collins, HIV i-Base<\/strong><\/p>\n<p>  A study published in the July 1st edition of JAIDS by Michelle Yong from The Alfred Hospital, Melbourne, reported a significant association between CD4 count and risk of fractures that was independent of traditional risk factors including corticosteroid use.<\/p>\n<p>  The group performed a 1:2 matched case-control study in HIV positive patients attending a single hospital site between 1998 and 2009. Controls were matched on gender, age, and duration of HIV infection.<\/p>\n<p>  The overall fracture incidence rate was 0.53 per 100 person-years (95%CI: 0.43 to 0.65) and period prevalence of 3.34 per 100 patients (95% CI: 2.66 to 4.13). There were 73 low trauma fractures in 61 patients. Patients were predominantly male (89%) with a mean age of 49.8 years. Independent risk factors for fragility fracture were a CD4 cell count &lt;200 cells\/mm3 (OR 4.91: 95% CI 1.78 to 13.57, p = 0.002), corticosteroids (OR 8.96: 95% CI 1.55 to 51.88, p = 0.014) and anti-epileptic medications (OR: 8.88: 95% CI 1.75 to 44.97, p = 0.008).<\/p>\n<p>  No association was found between risk of fracture and HIV viral load (p = 0.18), use of antiretrovirals or class of antiretroviral medication. The majority patients with fracture (88%) had osteopenia or osteoporosis.<\/p>\n<p>  Reference:<\/p>\n<p>  Yong MK et al. Low CD4 count is associated with an increased risk of fragility fracture in HIV-infected patients. JAIDS, 1 July 2011 &#8211; Volume 57 &#8211; Issue 3 &#8211; pp 205-210<br \/>\n  <a href=\"http:\/\/journals.lww.com\/jaids\/Fulltext\/2011\/07010\/Low_CD4_Count_Is_Associated_With_an_Increased_Risk.5.aspx\">http:\/\/journals.lww.com\/jaids\/Fulltext\/2011\/07010\/Low_CD4_Count_Is_Associated_With_an_Increased_Risk.5.aspx<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Simon Collins, HIV i-Base A study published in the July 1st edition of JAIDS by Michelle Yong from The Alfred Hospital, Melbourne, reported a significant association between CD4 count and risk of fractures that was independent of traditional risk factors &hellip;<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[31],"tags":[],"class_list":["post-15900","post","type-post","status-publish","format-standard","hentry","category-opportunistic-infections-coinfections-and-complications"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/15900","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=15900"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/15900\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=15900"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=15900"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=15900"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}