{"id":16332,"date":"2012-04-01T15:37:17","date_gmt":"2012-04-01T15:37:17","guid":{"rendered":"http:\/\/i-base.info\/htb\/?p=16332"},"modified":"2012-04-01T15:37:17","modified_gmt":"2012-04-01T15:37:17","slug":"case-report-homozygous-ccr5-delta-32-protection-overcome-by-infection-with-x4-virus","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/16332","title":{"rendered":"Case report: homozygous CCR5 delta-32 protection overcome by infection with X4 virus"},"content":{"rendered":"<p><strong><img loading=\"lazy\" decoding=\"async\" class=\"alignright size-full wp-image-16371\" title=\"CROI-logo-5-150x142\" src=\"https:\/\/i-base.info\/htb\/files\/2012\/04\/CROI-logo-5-150x142.png\" alt=\"\" width=\"150\" height=\"142\" \/>Simon Collins, HIV i-Base<\/strong><\/p>\n<p><strong>A sobering and important report documented the case study of a man who was homozygous for the CCR5 delta-32 mutation that generally provides effective protection against infection from HIV.<\/strong><\/p>\n<p>With most circulating (and infectious) virus using the CCR5 co-receptor, individuals with this deletion in both chromosomes who are exposed to HIV provide a dead-end for the infection, with the virus unable to infection CD4 cells without the use of the coreceptor.<\/p>\n<p>This case of a 39 year-old man &#8211; who was diagnosed in 1996 &#8211; was indentified by Ester Ballana and colleagues after retrospectively testing DNA from stored peripheral blood mononuclear cells (PBMCs). The man had started treatment within 6 months of diagnosis, at a CD4 count of 520 and viral load of 3,500 copies\/mL. Sequence analysis of the env gene idicated homogeneous X4 virus.<\/p>\n<p>Fifteen years after seroconversion, total HIV-1 proviral DNA was 60 copies\/million PBMCs. CD4 count had only increased to 600-700 over this time but HLA haplotype analysis showed multiple alleles associated with slower HIC progression including HLA-B*5701 and HLA-A*2402.<\/p>\n<p>Ref: Ballana E et al. HIV-1 infection in a CCR5-D32\/D32, HLA-B*5701, and HLA-A*2402 subject: a case report. Poster abstract 292.<\/p>\n<p><a href=\"http:\/\/www.retroconference.org\/2012b\/Abstracts\/43778.htm\">http:\/\/www.retroconference.org\/2012b\/Abstracts\/43778.htm<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Simon Collins, HIV i-Base A sobering and important report documented the case study of a man who was homozygous for the CCR5 delta-32 mutation that generally provides effective protection against infection from HIV. With most circulating (and infectious) virus using &hellip;<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,10],"tags":[66],"class_list":["post-16332","post","type-post","status-publish","format-standard","hentry","category-conference-reports","category-transmission-and-prevention","tag-croi-2012"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/16332","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=16332"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/16332\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=16332"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=16332"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=16332"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}