{"id":16541,"date":"2012-06-01T10:13:41","date_gmt":"2012-06-01T10:13:41","guid":{"rendered":"http:\/\/i-base.info\/htb\/?p=16541"},"modified":"2012-07-21T05:41:53","modified_gmt":"2012-07-21T05:41:53","slug":"interactions-between-malaria-drugs-and-etravirine-or-darunavirr","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/16541","title":{"rendered":"Interactions between malaria drugs and etravirine or darunavir\/r"},"content":{"rendered":"<p><strong><img loading=\"lazy\" decoding=\"async\" class=\"alignright size-full wp-image-16567\" title=\"13th PK logo\" src=\"https:\/\/i-base.info\/htb\/files\/2012\/05\/13th-PK-logo.png\" alt=\"\" width=\"160\" height=\"81\" \/>www.drug-interactions.org<\/strong><\/p>\n<p><strong>The interactions at steady state between artemether\/lumefantrine (40\/480 mg for three days) and etravirine (200 mg twice daily) or darunavir\/r (600\/100 mg twice daily) were investigated in two HIV negative groups (n=14 each). <\/strong><\/p>\n<p>Etravirine decreased the AUC of artemether, dihydroartemisinin and lumefantrine by 38%, 15% and 13%, respectively. Darunavir\/r decreased the AUCs of artemether (16%) and dihydroartimisin (18%) but increased lumefantrine AUC by 2.75-fold. Co-administration of artemether\/lumefantrine had no effect on the AUCs of etravirine, darunavir or ritonavir.<\/p>\n<p>The antimalarial activity of artemether may be lowered in the presence of etravirine and therefore, the combination should be used with caution.<\/p>\n<p>Pharmacokinetically, darunavir\/r can be co-administered with artemether\/lumefantrine without dose adjustment however co-administration is not recommended with other drugs that may cause QTc prolongation (such as lumefantrine).<\/p>\n<p>Reference:<\/p>\n<p>Kakuda T et al. Pharmacokinetic interaction between etravirine or darunavir\/ritonavir and artemether\/lumefantrine in healthy volunteers: a randomised trial. 13th PK Workshop, Barcelona, 2012. Oral abstract O_05.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>www.drug-interactions.org The interactions at steady state between artemether\/lumefantrine (40\/480 mg for three days) and etravirine (200 mg twice daily) or darunavir\/r (600\/100 mg twice daily) were investigated in two HIV negative groups (n=14 each). Etravirine decreased the AUC of artemether, &hellip;<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,34],"tags":[136],"class_list":["post-16541","post","type-post","status-publish","format-standard","hentry","category-conference-reports","category-pk-and-drug-interactions","tag-pk-workshop-13th-2012"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/16541","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=16541"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/16541\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=16541"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=16541"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=16541"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}