{"id":16553,"date":"2012-06-01T10:09:41","date_gmt":"2012-06-01T10:09:41","guid":{"rendered":"http:\/\/i-base.info\/htb\/?p=16553"},"modified":"2012-07-21T05:41:54","modified_gmt":"2012-07-21T05:41:54","slug":"milk-thistle-silymarin-and-darunavirritonavir","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/16553","title":{"rendered":"Milk thistle (silymarin) and darunavir\/ritonavir"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"alignright size-full wp-image-16567\" title=\"13th PK logo\" src=\"https:\/\/i-base.info\/htb\/files\/2012\/05\/13th-PK-logo.png\" alt=\"\" width=\"160\" height=\"81\" \/><strong>www.drug-interactions.org<\/strong><\/p>\n<p><strong>The effect of the botanical supplement milk thistle (silymarin, 150 mg every 8 hours) on the pharmacokinetics of darunavir\/ritonavir (600\/100 mg twice daily) was investigated in 15 HIV positive patients. <\/strong><\/p>\n<p>In the presence of milk thistle, Darunavir AUC, Cmax and Ctrough decreased by 14% (GMR 0.86: 90%CI 0.67-1.10), 17% (GMR 0.83; 90%CI 0.68-1.02) and 6% (GMR 0.94; 90% CI 0.70-1.26), respectively.<\/p>\n<p>As all patients had darunavir concentrations well above the median protein-binding-adjusted IC50, the study concluded that no dose adjustment for darunavir\/r appears to be necessary.<\/p>\n<p>Reference:<\/p>\n<p>Molto J et al. Effect of milk thistle on the pharmacokinetics of darunavir\/ritonavir in HIV-infected patients. 13th PK Workshop, 16-18 April 2012, Barcelona. Abstract: P_04.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>www.drug-interactions.org The effect of the botanical supplement milk thistle (silymarin, 150 mg every 8 hours) on the pharmacokinetics of darunavir\/ritonavir (600\/100 mg twice daily) was investigated in 15 HIV positive patients. In the presence of milk thistle, Darunavir AUC, Cmax &hellip;<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,34],"tags":[136],"class_list":["post-16553","post","type-post","status-publish","format-standard","hentry","category-conference-reports","category-pk-and-drug-interactions","tag-pk-workshop-13th-2012"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/16553","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=16553"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/16553\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=16553"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=16553"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=16553"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}