{"id":1757,"date":"2008-02-01T08:43:32","date_gmt":"2008-02-01T07:43:32","guid":{"rendered":"http:\/\/moomango.co.uk\/htb\/?p=1757"},"modified":"2013-08-30T11:23:38","modified_gmt":"2013-08-30T11:23:38","slug":"atazanavir-exposure-in-pregnancy","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/1757","title":{"rendered":"Atazanavir exposure in pregnancy"},"content":{"rendered":"<p><strong>Polly Clayden, HIV i-Base<\/strong><\/p>\n<p><strong>A paper authored by Ripamonti Diego from the Division of Infectious Diseases, Ospedali Riuniti, Bergamo, Italy and coworkers, published in the November 30 edition of AIDS, reported findings from a study looking at the pharmacokinectics and placental transfer of boosted atazanavir in a group of HIV-positive pregnant women.<\/strong><\/p>\n<p>Seventeen women, receiving atazanavir boosted with ritonavir (plus AZT and 3TC) completed the study. A steady-state 24 hour pharmacokinetic evaluation of atazanavir was performed in the third trimester of pregnancy performed (38 \u00b1 22 days, mean and SD) before delivery and postpartum. At the time of the evaluation the BMI of the women was 26.39 (SD \u00b1 0.7), significantly (p&lt;0.0001) higher than that reported from the postpartum evaluation (BMI 24.02 \u00b1 0.6) performed 71 \u00b1 45 days after delivery.<\/p>\n<p>Maternal and cord blood samples were obtained at delivery. The atazanavir was measured by reverse-phase high-performance liquid chromatography.<\/p>\n<p>The investigators found the antepartum atazanavir geometric mean AUC was 28 510 ng\u00b7h\/l, the Cmax was 2 591 ng\/ml and the Cmin was 486 ng\/ml. The same postpartum parameters were 30 465 ng\u00b7h\/l, 2 878 ng\/ml and 514 ng\/ml, respectively. The antepartum to postpartum ratio for AUC was 0.94 and for Cmin was 0.96 ie equivalent. Cmax values were slightly although not significantly lower.<\/p>\n<p>The ratio of cord blood\/maternal atazanavir concentration in 14 paired samples was 0.13.<\/p>\n<p>The investigators concluded: \u0093As pregnancy does not appear to alter plasma exposure to atazanavir, no dose adjustment is required in pregnant women. Pharmacokinetic results suggest that a standard boosted atazanavir dose is a reasonable component of HAART during pregnancy.\u0094<\/p>\n<p class=\"ref\">Reference:<\/p>\n<p class=\"ref\">Diego R, Dario C, Franco M et al. Atazanavir plus low-dose ritonavir in pregnancy: pharmacokinetics and placental transfer. AIDS. Volume 21(18),30 November 2007, p 2409-2415.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Polly Clayden, HIV i-Base A paper authored by Ripamonti Diego from the Division of Infectious Diseases, Ospedali Riuniti, Bergamo, Italy and coworkers, published in the November 30 edition of AIDS, reported findings from a study looking at the pharmacokinectics and &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[35],"tags":[],"class_list":["post-1757","post","type-post","status-publish","format-standard","hentry","category-pmtct-and-maternal-health"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/1757","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=1757"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/1757\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=1757"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=1757"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=1757"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}