{"id":19796,"date":"2012-08-01T12:15:54","date_gmt":"2012-08-01T12:15:54","guid":{"rendered":"http:\/\/i-base.info\/htb\/?p=19796"},"modified":"2012-08-16T16:35:35","modified_gmt":"2012-08-16T16:35:35","slug":"recombination-dynamics-in-case-of-mdr-sub-type-d-following-superinfection-with-wild-type-sub-type-b","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/19796","title":{"rendered":"Recombination dynamics in case of MDR sub-type D following superinfection with wild-type sub-type B"},"content":{"rendered":"<p><strong>Simon Collins, HIV i-Base<\/strong><\/p>\n<p><strong>While research into reinfection is largely driven by expanding number of case studies, Koning and colleagues from the UK described the dynamics of reinfection with wild-type virus, using single genome sequencing (SGS) in both plasma and semen samples.<\/strong><\/p>\n<p>Sequential plasmas sampling was performed over 87 weeks, with one semen sample, in a treatment naive patient. The initial sub-type D sample at diagnosis showed RT mutations at D67N, K70R, A98G, K101E, Y181C, G190A, T215L and K219E which was maintained at week 34. At 54 weeks, 18\/25 genomes remained similar to baseline, with 1\/25 wild-type sub-type B and 3\/25 recombinant B\/D sub-types with variable resistance.<\/p>\n<p>At weeks 85 and 87, only 2\/43 genomes related to the baseline sample, 3\/43 were drug-sensitive sub-type B and 39\/43 were B\/D recombinants, only one of which maintain drug resistant mutations.<\/p>\n<p>The single semen sample at week 87 showed 18\/21 of genomes sampled to be sub-type B, and the remaining three B\/D recombinants all to be drug sensitive.<\/p>\n<p>No data was presented on subsequent patient treatment history.<\/p>\n<p>Reference:<\/p>\n<p>Koning FA et al. Dynamics of recombination in HIV-1 following superinfection described using single genome sequencing. 20th Intl Drug Resistance Workshop, 5\u20139 June 2012, Sitges. Abstract 62. Antiviral Therapy 2012: 17 Suppl 1:A77.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Simon Collins, HIV i-Base While research into reinfection is largely driven by expanding number of case studies, Koning and colleagues from the UK described the dynamics of reinfection with wild-type virus, using single genome sequencing (SGS) in both plasma and &hellip;<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,36],"tags":[158],"class_list":["post-19796","post","type-post","status-publish","format-standard","hentry","category-conference-reports","category-drug-resistance","tag-idrw-21st-2012"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/19796","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=19796"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/19796\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=19796"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=19796"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=19796"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}