{"id":20296,"date":"2012-10-01T12:00:55","date_gmt":"2012-10-01T12:00:55","guid":{"rendered":"http:\/\/i-base.info\/htb\/?p=20296"},"modified":"2012-10-05T17:05:06","modified_gmt":"2012-10-05T17:05:06","slug":"case-report-fluticasone-fluconazole-and-ritonavir-interactions","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/20296","title":{"rendered":"Case report: fluticasone, fluconazole and ritonavir interactions"},"content":{"rendered":"<p><strong>www.hiv-druginteractions.org<\/strong><\/p>\n<p><strong>This case report further highlights the well documented interaction of a ritonavir-boosted PI and inhaled fluticasone but also describes an added interaction issue with the introduction of fluconazole for oral candidiasis.\u00a0<\/strong><\/p>\n<p>Within days of discontinuing fluticasone and initiating fluconazole, the 52 year old man was confirmed with exogenous Cushing&#8217;s syndrome and secondary adrenal insufficiency. The authors propose that fluconazole inhibits adrenal steroidogenesis and thereby has an adrenal inhibitory effect.<\/p>\n<p>Source: hiv-druginteractions.org (27 July 2012).<br \/>\n<a href=\"http:\/\/www.hiv-druginteractions.org\">http:\/\/www.hiv-druginteractions.org<\/a><\/p>\n<p>Reference:<\/p>\n<p>St Clair K, Maguire JD. Role of fluconazole in a case of rapid onset ritonavir and inhaled fluticasone-associated secondary adrenal insufficiency. Int J STD AIDS, 2012, 23(5): 371-372.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22648897\">http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22648897<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>www.hiv-druginteractions.org This case report further highlights the well documented interaction of a ritonavir-boosted PI and inhaled fluticasone but also describes an added interaction issue with the introduction of fluconazole for oral candidiasis.\u00a0 Within days of discontinuing fluticasone and initiating fluconazole, &hellip;<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[34],"tags":[],"class_list":["post-20296","post","type-post","status-publish","format-standard","hentry","category-pk-and-drug-interactions"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/20296","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=20296"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/20296\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=20296"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=20296"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=20296"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}