{"id":20298,"date":"2012-10-01T12:01:14","date_gmt":"2012-10-01T12:01:14","guid":{"rendered":"http:\/\/i-base.info\/htb\/?p=20298"},"modified":"2012-10-05T16:40:13","modified_gmt":"2012-10-05T16:40:13","slug":"ritonavir-interaction-with-quinine-is-clinically-insignificant-but-may-warrant-caution","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/20298","title":{"rendered":"Ritonavir interaction with quinine is clinically insignificant but may warrant caution"},"content":{"rendered":"<p><strong>www.hiv-druginteractions.org<\/strong><\/p>\n<p><strong>Coadministration of ritonavir (100 mg twice daily) and quinine (105.3, 162, 210.6 or 648 mg single doses) was studied in 4 groups of HIV negative subjects (n=20 per group).\u00a0<\/strong><\/p>\n<p>Quinine did not have a significant effect on ritonavir Tmax or Cmax, but increased AUC from 9.2 \u00b1 2.21 ug.h\/ml to 11.1 \u00b1 3.96 ug.h\/ml.<\/p>\n<p>Similarly, ritonavir had no significant effect on quinine pharmacokinetics (Cmax 4.3 \u00b1 1.07 vs 3.9 \u00b1 0.88 ug\/ml, AUC 78.9 \u00b1 26.78 vs 68.4 \u00b1 22.29 ug.h\/ml, alone vs with ritonavir). Although the increased ritonavir exposure and decreased quinine exposure are unlikely to be of clinical significance, caution should be exercised if coadministered.<\/p>\n<p>Source: hiv-druginteractions.org (31 July 2012).<br \/>\n<a href=\"http:\/\/www.hiv-druginteractions.org\">http:\/\/www.hiv-druginteractions.org<\/a><\/p>\n<p>Reference:<\/p>\n<p>Wason S et al. Lack of clinically significant pharmacokinetic interactions between quinine and ritonavir in healthy adult participants. International Workshop on Comorbidities and Adverse Drug Reactions in HIV, Washington, July 2012. Abstract P21.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>www.hiv-druginteractions.org Coadministration of ritonavir (100 mg twice daily) and quinine (105.3, 162, 210.6 or 648 mg single doses) was studied in 4 groups of HIV negative subjects (n=20 per group).\u00a0 Quinine did not have a significant effect on ritonavir Tmax &hellip;<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[34],"tags":[],"class_list":["post-20298","post","type-post","status-publish","format-standard","hentry","category-pk-and-drug-interactions"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/20298","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=20298"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/20298\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=20298"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=20298"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=20298"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}