{"id":2063,"date":"2007-12-01T23:23:57","date_gmt":"2007-12-01T22:23:57","guid":{"rendered":"http:\/\/moomango.co.uk\/htb\/?p=2063"},"modified":"2013-09-12T16:02:25","modified_gmt":"2013-09-12T16:02:25","slug":"atazanavir-with-or-without-ritonavir-may-increase-buprenorphine-and-buprenorphine-metabolites-requiring-dose-adjustment","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/2063","title":{"rendered":"Atazanavir, with or without ritonavir, may increase buprenorphine and buprenorphine metabolites, requiring dose adjustment"},"content":{"rendered":"<p><strong>HIV-druginteractions.org<\/strong><\/p>\n<p><strong>This study examined the interaction between buprenorphine and atazanavir (400 mg once daily) or atazanavir\/ritonavir (300\/100 mg once daily) in opioid-dependent, buprenorphine\/naloxone-maintained, HIV-negative volunteers. Pharmacokinetics of atazanavir and atazanavir\/ritonavir were compared in subjects and matched, healthy controls (n=10 per group) to determine effects of buprenorphine. Objective opiate withdrawal scale scores and mini-mental state examination were determined prior to and following antiretroviral administration to examine pharmacodynamic effects.<\/strong><\/p>\n<p>When coadministered with atazanavir, buprenorphine AUC increased from 39.5 to 76.3 ng.h\/ml; a similar increase was observed when coadministered with atazanavir\/ritonavir (46.2 to 77.0 ng.h\/ml). Concentrations of norbuprenorphine, buprenorphine glucuronide, and norbuprenorphine glucuronide also increased with both atazanavir and atazanavir\/ritonavir. The likely complex mechanism is discussed. Buprenorphine did not significantly alter atazanavir or ritonavir concentrations. Three buprenorphine\/naloxone-maintained participants reported increased sedation with atazanavir\/ritonavir.<\/p>\n<p>Atazanavir or atazanavir\/ritonavir may increase buprenorphine and buprenorphine metabolite concentrations and might require a decreased buprenorphine dose.<\/p>\n<p><a href=\"http:\/\/www.hiv-druginteractions.org\/new\/Content.asp?ID=345&amp;TDM=\">http:\/\/www.hiv-druginteractions.org\/new\/Content.asp?ID=345&amp;TDM=<\/a><\/p>\n<p>Reference:<\/p>\n<p>McCance-Katz EF, Moody DE, Morse GD et al. Interaction between buprenorphine and atazanavir or atazanavir\/ritonavir. Drug Alcohol Depend, 2007, 91(2-3): 269-278.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>HIV-druginteractions.org This study examined the interaction between buprenorphine and atazanavir (400 mg once daily) or atazanavir\/ritonavir (300\/100 mg once daily) in opioid-dependent, buprenorphine\/naloxone-maintained, HIV-negative volunteers. Pharmacokinetics of atazanavir and atazanavir\/ritonavir were compared in subjects and matched, healthy controls (n=10 per &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[34],"tags":[],"class_list":["post-2063","post","type-post","status-publish","format-standard","hentry","category-pk-and-drug-interactions"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/2063","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=2063"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/2063\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=2063"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=2063"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=2063"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}