{"id":21263,"date":"2013-04-01T11:51:03","date_gmt":"2013-04-01T11:51:03","guid":{"rendered":"http:\/\/i-base.info\/htb\/?p=21263"},"modified":"2013-04-03T09:39:00","modified_gmt":"2013-04-03T09:39:00","slug":"tuberculosis-mva85a-vaccine-trial-shows-lack-of-efficacy-in-infants","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/21263","title":{"rendered":"Tuberculosis MVA85A vaccine trial shows lack of efficacy in infants"},"content":{"rendered":"<p><strong>Richard Jefferys, TAG<\/strong><\/p>\n<p><strong>On 4 Feburary 2013, results from the phase IIb trial of the MVA85A vaccine in 2,797 infants in South Africa (given as a booster following BCG immunisation) were published in the Lancet.<\/strong> [1]<\/p>\n<p>The vaccine proved safe but, disappointingly, failed to show signifcant efficacy. However, as the researchers note, this was the first infant efficacy trial of a new TB vaccine since BCG was last assessed as part of the Chingleput trial in 1968; as such, it is a major milestone for the field, and analyses of the results, including assessments of the immune responses induced by the vaccine, will make a vital contribution to advancing the development of new vaccine candidates.<\/p>\n<p>Results from trials in adults are pending, and it remains uncertain if the lack of efficacy in infants will be mirrored in the adult setting.<\/p>\n<p>MVA85A is a recombinant attenuated version of the vaccinia virus (cowpox) combined with TB antigen 85A. It was developed at Oxford University and is being evaluated as a booster of preexisting immune responses to antigen 85A, which are present in most people either as a result of BCG vaccination or natural exposure to TB.<\/p>\n<p>Reference:<\/p>\n<p>Tameris MD et al. Safety and efficacy of MVA85A, a new tuberculosis vaccine, in infants previously vaccinated with BCG: a randomised, placebo-controlled phase 2b trial. The Lancet, early online publication. 4 February 2013. doi:10.1016\/S0140-6736(13)60177-4.<\/p>\n<p><a href=\"http:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736%2813%2960177-4\/abstract\">http:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736%2813%2960177-4\/abstract<\/a><\/p>\n<p>Lancet commentary:<\/p>\n<p><a href=\"http:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736(13)60137-3\/fulltext\">http:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736(13)60137-3\/fulltext<\/a><\/p>\n<p>Press release from trial sponsors:<\/p>\n<p><a href=\"http:\/\/www.aeras.org\/newscenter\/downloads\/news\/aeras_news_1344.pdf\">http:\/\/www.aeras.org\/newscenter\/downloads\/news\/aeras_news_1344.pdf<\/a> (PDF)<\/p>\n<p>i-Base\/TAG annual TB pipeline report:<\/p>\n<p><a href=\"http:\/\/www.pipelinereport.org\/TOC\/tuberculosis-vaccine\">http:\/\/www.pipelinereport.org\/TOC\/tuberculosis-vaccine<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Richard Jefferys, TAG On 4 Feburary 2013, results from the phase IIb trial of the MVA85A vaccine in 2,797 infants in South Africa (given as a booster following BCG immunisation) were published in the Lancet. [1] The vaccine proved safe &hellip;<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[37],"tags":[],"class_list":["post-21263","post","type-post","status-publish","format-standard","hentry","category-tb-coinfection"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/21263","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=21263"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/21263\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=21263"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=21263"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=21263"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}