{"id":22018,"date":"2013-07-25T10:23:14","date_gmt":"2013-07-25T10:23:14","guid":{"rendered":"http:\/\/i-base.info\/htb\/?p=22018"},"modified":"2013-07-25T13:07:09","modified_gmt":"2013-07-25T13:07:09","slug":"one-in-five-people-with-recent-hiv-infection-in-spain-have-x4r5-mixed-tropic-virus","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/22018","title":{"rendered":"One in five people with recent HIV infection in Spain have X4\/R5 mixed tropic virus"},"content":{"rendered":"

<\/strong>\"\"<\/strong>Simon Collins, HIV i-Base<\/p>\n

A retrospective Spanish database study reported very high levels of X4 infections in an anonymised population based surveillance study.<\/strong><\/p>\n

The study presented by Rocio Sierra-Enguita from Hospital Carlos III in Madrid, of 1031 people diagnosed from 1997 – 2012 with primary HIV infection (PHI), reported that approximately 23% of samples since 2010 indicated X4-tropism. This was significantly increased from levels at approximately 11% for the years prior to 2003, (p=0.03). Non-B subtypes were not detected from 1997-2000 but were at 18% from 2010-2012, p=0.003).<\/p>\n

The median time of diagnosis since infection was estimated at 5 months (IQR 5 to 10), with median CD4 and viral load at diagnosis of 533 cells\/mm3 (IQR 408 – 737) and 4.5 log copies\/mL (IQR 4.1 – 5.0), respectively. Approximately 13% of PHI patients were non-B subtype and 84% were MSM.<\/p>\n

Unfortunately, the anonymity of study design limited the ability to look for risk factors that might explain the increases.<\/p>\n

Reference:<\/p>\n

Sierra-Enguita R et al. X4 tropic viruses are on the rise in recent HIV-1 seroconverters. International Workshop on HIV and Hepatitis Virus Drug Resistance and Curative Strategies, 4-8 June 2013, Toronto. Oral abstract 14.
\nhttp:\/\/www.intmedpress.com\/journals\/avt\/abstract.cfm?id=2658&pid=88<\/a> (abstract book)
\nhttp:\/\/www.informedhorizons.com\/resistance2013\/pdf\/Presentations\/SierraEnguita.pdf<\/a> (PDF slides)<\/p>\n


\n<\/strong><\/div>\n","protected":false},"excerpt":{"rendered":"

Simon Collins, HIV i-Base A retrospective Spanish database study reported very high levels of X4 infections in an anonymised population based surveillance study. The study presented by Rocio Sierra-Enguita from Hospital Carlos III in Madrid, of 1031 people diagnosed from …<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,43],"tags":[179],"class_list":["post-22018","post","type-post","status-publish","format-standard","hentry","category-conference-reports","category-virology","tag-idrw-toronto-2013"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/22018","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=22018"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/22018\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=22018"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=22018"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=22018"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}