{"id":2340,"date":"2006-08-03T17:50:49","date_gmt":"2006-08-03T16:50:49","guid":{"rendered":"http:\/\/moomango.co.uk\/htb\/?p=2340"},"modified":"2013-12-06T17:29:38","modified_gmt":"2013-12-06T17:29:38","slug":"k103n-containing-variants-persist-longer-in-women-with-subtype-d-and-with-higher-viral-loads","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/2340","title":{"rendered":"K103N containing variants persist longer in women with subtype D and with higher viral loads"},"content":{"rendered":"

Polly Clayden, HIV i-Base<\/strong><\/p>\n

A group of women who had received single dose nevirapine in the HIVNET 012 trial were enrolled in a long-term (up to five years) follow-up study.<\/strong><\/p>\n

Tamara Flys and coworkers from John Hopkins, analysed plasma samples from 184 of these women. The group included 39 women who were re-exposed to single dose nevirapine in one or two subsequent pregnancies. The LigAmp sensitive and quantitative point mutation assay (cutoff: 0.5% K103N) was used to detect the K103N mutation.<\/p>\n

The authors reported a cumulative percentage of women with undetectable K103N of 58.6% by 6\u00968 weeks, 85.2% by 2 years, 92.1% by 3 years, 99.1% by 4 years, and 99.1% by 5 years among women receiving only single dose nevirapine in one pregnancy.<\/p>\n

They found that the rate of \u0093fading\u0094 of detectable K103N containing variants was slower in women with subtype D than A.<\/p>\n

In multivariate analysis, sub types (D versus. A, HR: 0.50, 95% CI: 0.33\u00960.76, p=0.0005) and pre-nevirapine viral load (per log increase, HR: 0.63, 95% CI: 0.48\u00960.83, p=0.0007), were independently associated with slower fading, while baseline CD4 cell count was not.<\/p>\n

Of the 39 women who received single dose nevirapine for subsequent pregnancies during the follow-up study, most had undetectable K103N within a year of re-exposure.<\/p>\n

They also found that when K103N was detected, it was present at low levels, and \u0093faded\u0094 from detection within 1 year of additional follow-up.<\/p>\n

The authors concluded that K103N was undetectable in plasma from most women within 6\u00968 weeks of receiving single dose nevirapine in pregnancy, and in plasma from all evaluable women within 4 years. This included women who were re-exposed to single dose nevirapine in a subsequent pregnancy during the follow-up period. They noted, \u0093K103N-containing variants persisted longer in women with subtype D and in women with higher baseline viral loads.\u0094<\/p>\n

Reference:<\/p>\n

Flys TS, Mwatha A, Donnell D et al. Fading of K103N-containing HIV-1 variants after initial and repeated exposure to single dose nevirapine for prevention of HIV-1 mother-to-child transmission (HIVNET 012). XV International HIV Drug Resistance Workshop, Sitges, Spain, July 2006. Abstract 46.<\/p>\n","protected":false},"excerpt":{"rendered":"

Polly Clayden, HIV i-Base A group of women who had received single dose nevirapine in the HIVNET 012 trial were enrolled in a long-term (up to five years) follow-up study. Tamara Flys and coworkers from John Hopkins, analysed plasma samples …<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,36],"tags":[112],"class_list":["post-2340","post","type-post","status-publish","format-standard","hentry","category-conference-reports","category-drug-resistance","tag-idrw-15th-2006"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/2340","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=2340"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/2340\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=2340"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=2340"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=2340"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}